57159-62-3
中文名稱
3-(溴乙酸酰基)丙酸琥珀酰亞胺酯
英文名稱
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
CAS
57159-62-3
分子式
C9H11BrN2O5
分子量
307.1
MOL 文件
57159-62-3.mol
更新日期
2024/12/22 16:36:06
57159-62-3 結(jié)構(gòu)式
基本信息
中文別名
3-(溴乙酸?；?丙酸琥珀酰亞胺酯琥珀酰亞胺基 3-(溴乙酰氨基)丙酸酯
英文別名
SBAPSUCCINIMIDYL 3-[BROMOACETAMIDO]PROPIONATE
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
SucciniMidyl 3-(broMoacetaMido)propionate(SBAP)
Succinimidyl 3-(bromoacetamido)propionate≥ 98% (HPLC)
2-BroMo-N-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]acetaMide
物理化學(xué)性質(zhì)
熔點(diǎn)93-94°C
密度1.69±0.1 g/cm3(Predicted)
儲(chǔ)存條件Inert atmosphere,Store in freezer, under -20°C
溶解度可溶于氯仿（輕微，加熱），甲醇（輕微）
酸度系數(shù)(pKa)12.96±0.46(Predicted)
形態(tài)固體
顏色灰白色至白色蠟狀
CAS 數(shù)據(jù)庫(kù)57159-62-3
常見(jiàn)問(wèn)題列表
生物活性
N-Succinimidyl 3-(Bromoacetamido)propionate 是一種 PROTAC linker，屬于 PEG 類(lèi)?？捎糜诤铣蒔ROTAC分子。N-Succinimidyl 3-(Bromoacetamido)propionate 也是一種可降解 (cleavable) 的 ADC linker，可用于合成抗體偶聯(lián)藥物 (ADC)。靶點(diǎn)
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PEGs
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Alkyl/ether
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Cleavable
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體外研究
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.