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53101-49-8

中文名稱 (R)-(+)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
英文名稱 (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
CAS 53101-49-8
分子式 C14H18O4
分子量 250.29
MOL 文件 53101-49-8.mol
53101-49-8 結(jié)構(gòu)式 53101-49-8 結(jié)構(gòu)式

基本信息

中文別名
(R)-(+)-6-羥基-2,5,7,8-四甲基沒-2-羧酸
(R)-(+)-6-羥基-2,5,7,8-四甲基色烷-2-羧酸
(R)-(+)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
英文別名
(R)-Trolox
(R)-Trolox D5
Trolox (R)-Isomer
Trolox Impurity 1 (Trolox (R)-Isomer)
(R)-(+)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-C
(2R)-2,5,7,8-Tetramethyl-6-hydroxychroman-2-carboxylic acid
(R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
(R)-(+)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 98%
(R)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
(2R)-6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

物理化學(xué)性質(zhì)

熔點162 °C (dec.) (lit.)
沸點450.3±45.0 °C(Predicted)
密度1.219±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 250 mg/mL (998.84 mM)
酸度系數(shù)(pKa)3.35±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
旋光性 (optical activity)[α]27/D +65°, c = 1.2 in ethanol

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
危險品標(biāo)志Xi
危險類別碼36/37/38
安全說明26-37/39
WGK Germany3
海關(guān)編碼9999999999
(R)-(+)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-101445A(R)-(+)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
(R)-Trolox
53101-49-850mg510元
2024/11/08HY-101445A(R)-(+)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
(R)-Trolox
53101-49-810mM * 1mLin DMSO561元
2024/11/08HY-101445A(R)-(+)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
(R)-Trolox
53101-49-8100mg820元

常見問題列表

生物活性
(R)-Trolox 是水溶性維生素 E 類似物,是一種競爭性酪氨酸酶抑制劑,Ki 值為 0.83 mM,ID50 值為 1.88 mM。(R)-Trolox 具有比 (S) 對映異構(gòu)體更強的酪氨酸酶親和力 (Ki 值為 0.61 mM)。
體外研究

As compared to the control containing no inhibitor, DMSO suppresses the tyrosinase activity at tested levels, 100 and 200 μL in a total volume of 3.0 mL. The inhibition of DMSO on the mushroom tyrosinase is dosedependent. Additions of DMSO at the two levels in the tyrosinase digests containing (R)-Trolox ((R)-HTCCA) results in further inhibitions of the tyrosinase activity. The influence of the DMSO on the inhibitory effects of (R)-Trolox against the tyrosinase is also dose-dependent.

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