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53174-06-4

中文名稱 (S)-(-)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
英文名稱 (S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
CAS 53174-06-4
分子式 C14H18O4
分子量 250.29
MOL 文件 53174-06-4.mol
53174-06-4 結(jié)構(gòu)式 53174-06-4 結(jié)構(gòu)式

基本信息

中文別名
(S)-()-6-羥基-2,5,7,8-四甲基色烷-2-羧酸
(S)-(-)-6-羥基-2,5,7,8-四甲基色滿-2-羧酸
英文別名
Trolox (S)-Isomer
Trolox Impurity 2 (Trolox (S)-Isomer)
(S)-(-)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-C
(2S)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
(S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
(S)-(-)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 98%
(S)-6-Hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
(S)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
(2S)-2,5,7,8-Tetramethyl-6-hydroxy-3,4-dihydro-2H-1-benzopyran-2α-carboxylic acid

物理化學(xué)性質(zhì)

熔點160 °C (dec.) (lit.)
沸點450.3±45.0 °C(Predicted)
密度1.219±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度Acetonitrile (Slightly), Chloroform (Slightly, Sonicated), Methanol (Slightly)
酸度系數(shù)(pKa)3.35±0.20(Predicted)
形態(tài)固體
顏色白色至淺米色
旋光性 (optical activity)[α]26/D 65°, c = 1.2 in ethanol

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
危險品標(biāo)志Xi
危險類別碼36/37/38
安全說明26-37/39
WGK Germany3

應(yīng)用領(lǐng)域

用途1
色滿具有α-生育酚手性中心。

常見問題列表

生物活性
(S)-Trolox 是維生素 E 的類似物,其中的植酸基鏈被羧基取代。(S)-Trolox 經(jīng)常用作研究結(jié)構(gòu)特征的模型化合物,以及作為評估抗氧化劑活性的標(biāo)準(zhǔn)。(S)-Trolox 具有有效而特定的神經(jīng)保護(hù)和抗氧化作用。
體外研究

The neuroprotective efficacy of antioxidant molecules against iodoacetate (IAA) neurotoxicity in rat cerebellar granule cell (CGC) cultures is investigated. In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80–100% of control cultures. (S)-Trolox displays EC50 value of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox with an IC50 value of 97 μM. The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH.

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