511-96-6
511-96-6 結(jié)構(gòu)式
基本信息
支脫皂苷元
芰脫皂甙元
吉托皂苷元
芰脫皂苷元
支托皂苷元
支脫皂苷元對照品
支脫皂苷元標準品
吉托皂苷元(標準品)
吉托皂苷元(芰脫皂甙元)
Digine
GITOGENIN
NSC 147752
2alpha-Hydroxytigogenin
Gitogenin NSC 147752
(2a,3b,5a,25R)-Spirostan-2,3-diol
(25R)-2α,3β-Dihydroxy-5α-spirostan
(25R)-2α,3β-Dihydroxy-5α-spirostane
Spirostan-2,3-diol, (2α,3β,5α,25R)-
物理化學性質(zhì)
常見問題列表
IC50: 0.69 μM (UDP-glucuronosyltransferase 1A4); IC50: 37.2 μM (α-glucosidase)
When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC 50 value of 6.13 μM. Similarly, for midazolam as the substrate of UGT1A4, the IC 50 value is 5.7 μM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC 50 value is determined as 6.0 μM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC 50 value of 22.0 μM.
Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) shows rat growth-hormone (rGH) release stimulating activities (26.1 ng/mL).