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50-49-7

中文名稱 米帕明
英文名稱 IMIPRAMINE
CAS 50-49-7
分子式 C19H24N2
分子量 280.41
MOL 文件 50-49-7.mol
更新日期 2023/03/20 15:41:19
50-49-7 結(jié)構(gòu)式 50-49-7 結(jié)構(gòu)式

基本信息

中文別名
米帕明
丙米嗪
氯米帕明雜質(zhì)10
化合物 T20025
丙咪嗪(氯丙咪嗪EP雜質(zhì)B)
丙咪嗪系統(tǒng)適應(yīng)性 EP標(biāo)準(zhǔn)品
英文別名
IM
DPID
Irmin
Iramil
Imizin
Imiprin
Imizine
Surplix
Timolet
Censtim
所屬類別
原料藥:抗抑郁、躁狂藥

物理化學(xué)性質(zhì)

熔點(diǎn)174°C
沸點(diǎn)bp0.1 160°
密度0.9935 (rough estimate)
折射率1.5640 (estimate)
酸度系數(shù)(pKa)pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
形態(tài)Liquid
顏色Colorless to light yellow
水溶解性18.23mg/L(24 ºC)
Concentration1 mCi/ml
SolventEthanol under nitrogen
Specific Activity60-90 Ci/mmol
BCS Class1
EPA化學(xué)物質(zhì)信息Imipramine (50-49-7)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H302-H336-H370-H400
毒害物質(zhì)數(shù)據(jù)50-49-7(Hazardous Substances Data)
毒性A tertiary amine tricyclic antidepressant that is thought to exert its therapeutic effect by inhibiting the reuptake of serotonin and norepinephrine centrally. A major metabolite is N-desmethylimipramine (desipramine), also used as an antidepressant drug. Desipramine differs from imipramine in being a better blocker of norepinephrine, rather than serotonin, uptake. Side effects, including sedation and drowsiness, dry mouth, urinary retention, constipation, and orthostatic hypotension, are probably due to the anticholinergic, anti-α-adrenergic, and antihistaminergic receptor-blocking properties. Imipramine should not be used in conjunction with a monoamine oxidase inhibitor or other treatment that increases catecholamine concentrations (e.g., drugs containing sympathomimetic amines). Imipramine should be avoided in patients with cardiovascular disease or seizure disorder, or in those who may abuse alcohol, as imipramine lowers seizure threshold, can produce cardiovascular toxicity and may potentiate the effects of alcohol. Imipramine intoxication can include CNS abnormalities (e.g., drowsiness, stupor, coma, and extrapyramidal symptoms), cardiac arrhythmia, and respiratory depression. Children appear to be particularly vulnerable to the cardiotoxic and seizure-inducing effects of high doses of imipramine. The oral LD50 in female rats is 305 mg/kg.

制備方法

方法1

由鄰硝基甲苯經(jīng)縮合、還原得2,2′-氨基聯(lián)芐與1-氯-3-二甲氨基丙烷縮合、成鹽制得。

上下游產(chǎn)品信息

下游產(chǎn)品
鹽酸丙咪嗪
"50-49-7" 相關(guān)產(chǎn)品信息
494-19-9 303-49-1 17321-77-6 113-52-0