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42079-78-7

中文名稱 5-甲氧基黃酮
英文名稱 5-METHOXYFLAVONE
CAS 42079-78-7
EINECS 編號 255-652-0
分子式 C16H12O3
MDL 編號 MFCD00016942
分子量 252.26
MOL 文件 42079-78-7.mol
更新日期 2023/03/20 19:41:21
42079-78-7 結(jié)構(gòu)式 42079-78-7 結(jié)構(gòu)式

基本信息

中文別名
甲氧基黃酮
5-甲氧基黃酮,97%
英文別名
5-METHOXYFLAVONE
METHOXYFLAVONE, 5-
5-methoxy-2-phenyl-4-benzopyrone
5-Methoxyflavone,97%
5-Methoxy-2-phenyl-4H-1-benzopyran-4-one
所屬類別
生物化工:提取物

物理化學(xué)性質(zhì)

熔點131-133°C
沸點422.5±45.0 °C(Predicted)
密度1,155g/cm
折射率1,548
儲存條件-20°C儲存
溶解度溶于甲醇
形態(tài)粉末晶體
顏色白色到近乎白色
LogP3.470 (est)
CAS 數(shù)據(jù)庫42079-78-7(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
危險品標(biāo)志Xi
危險類別碼R36/37/38
安全說明S26-S36/37/39
WGK Germany3
海關(guān)編碼2932.99.7000

知名試劑公司產(chǎn)品信息

5-甲氧基黃酮價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-1077905-甲氧基黃酮
5-Methoxyflavone
42079-78-725mg500元
2024/11/08M23655-甲氧基黃酮
5-Methoxyflavone
42079-78-71g660元
2024/11/08S47825-甲氧基黃酮
5-methoxyflavone
42079-78-725mg794.68元

常見問題列表

生物活性
5-Methoxyflavone,是一種類黃酮,是DNA聚合酶 β (DNA polymerase-beta) 的抑制劑和 β-淀粉樣蛋白毒性的神經(jīng)保護劑。擁有中樞神經(jīng)系統(tǒng)鎮(zhèn)靜劑的作用,通過調(diào)控嗜離子 GABAA 受體來實現(xiàn)。
靶點
TargetValue
DNA polymerase β
()
體外研究

5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. 5-methoxyflavone (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate.
5-Methoxyflavone (5-MF, 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner.

體內(nèi)研究

5-Methoxyflavone (100, 150 mg/kg, i.p) significantly decreases the latency time to loss of righting reflex. 5-Methoxyflavone (50, 100 and 150 mg/kg, i.p) exhibits a significant and dose-dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, i.p) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, i.p) completely abolishesed the grooming response similar to diazepam treated animals.

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