34576-94-8
中文名稱
3,6-二氯-2-苯并噻吩羧酸
英文名稱
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
CAS
34576-94-8
分子式
C9H4Cl2O2S
分子量
247.1
MOL 文件
34576-94-8.mol
34576-94-8 結(jié)構(gòu)式
基本信息
中文別名
3,6-二氯苯并噻吩-2-甲酸3,6-二氯苯并噻吩-2-羧酸
3,6-二氯-2-苯并噻吩羧酸
3,6-二氯-1-苯并噻吩-2-羧酸
3,6-二氯苯并[B]噻吩-2-羧酸
英文別名
BT23,6-dichlorobenzothiophene-2-carboxylic acid
3,6-dichloro-2-benzothiophenecarboxylic acid
3,6-Dichloro-1-benzothiophene-2-carboxylicaci
Benzo[b]thiophene-2-carboxylic acid, 3,6-dichloro-
JR-6478, 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid, 97%
所屬類別
有機(jī)原料：雜環(huán)化合物物理化學(xué)性質(zhì)
沸點(diǎn)426.4±40.0 °C(Predicted)
密度1.653±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度可溶于DMSO（高達(dá)至少20mg/ml）
酸度系數(shù)(pKa)2.09±0.30(Predicted)
形態(tài)固體
顏色米白色
穩(wěn)定性可在-20°C的DMSO中的溶液下儲(chǔ)存長(zhǎng)達(dá)3個(gè)月。
常見(jiàn)問(wèn)題列表
用途
3,6-二氯-2-苯并噻吩羧酸用作研究用化合物。生物活性
BT2 是 BCKDC 激酶 (BDK) 抑制劑，IC50 值為 3.19 μM。BT2 與 BDK 的結(jié)合會(huì)觸發(fā)支鏈 α-酮酸脫氫酶復(fù)合物 (BCKDC) 的 N 末端結(jié)構(gòu)域的螺旋運(yùn)動(dòng)，從而導(dǎo)致 BDK 與 BCKDC 分離。BT2 (compound 4) 也是一種有效的選擇性的 Mcl-1 抑制劑，Ki 值為 59 μM。靶點(diǎn)
|
BDK 3.19 μM (IC 50 ) |
Mcl-1 59 μM (Ki) |
體內(nèi)研究
BT2 (20 mg/kg/day; intraperitoneal injection; daily; for 7 days; C57BL/6J male mice) treatment robustly enhances BCKDC activity in the heart (12.3-fold) compared with the vehicle-treated animals. Less activation is obtained in muscle and kidney at 3.6- and 3.8-fold, respectively. The -fold activation of BCKDC activity in the above tissues correlates with decreased phosphorylation in heart, muscle, and kidney after the long term BT2 treatment. BT2 treatment reduces the protein levels of BDK in kidneys and heart.
| Animal Model: | C57BL/6J male mice (8-10-week-old) |
| Dosage: | 20 mg/kg/day |
| Administration: | Intraperitoneal injection; daily; for 1 week |
| Result: | BCKDC activity was robustly (12.3-fold) enhanced in the heart compared with the vehicle-treated animals. Less activation was obtained in muscle and kidney at 3.6- and 3.8-fold, respectively. The protein levels of BDK in kidneys and heart were reduced to averages of 39 and 24%, respectively. |