33401-94-4
中文名稱
酒石酸噻吩嘧啶
英文名稱
PYRANTEL TARTRATE SALT
CAS
33401-94-4
分子式
C15H20N2O6S
分子量
356.39
MOL 文件
33401-94-4.mol
更新日期
2024/12/27 15:00:12
33401-94-4 結(jié)構(gòu)式
基本信息
中文別名
酒石酸噻嘧啶酒石酸噻吩嘧啶
英文別名
cp10423-18Pyrantel Tartate
PYRANTEL TARTRATE SALT
pyrantel hydrogen tartrate
PYRANTEL TARTRATE SALT ISO 9001：2015 REACH
(E)-4,5,6-TETRAHYDRO-1-METHYL-2-(2-(2-THIENYL)ETHENYL)PYRIMIDINE
(e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidinetartrate(1:
1-METHYL-2-[2-(2-THIENYL)ETHENYL]-1,4,5,6-TETRAHYDROPYRIMIDINE TARTRATE SALT
(E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine tartrate (1:1)
1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-pyrimidin(e)-pyrimidintartrate
所屬類別
醫(yī)藥中間體：噻吩嘧啶物理化學(xué)性質(zhì)
熔點148-150°
儲存條件Inert atmosphere,Room Temperature
溶解度H2O中可溶 4.0ML，透明，無色至淡黃色或棕褐色（溶劑：200 mg 加 4.0 mL）
形態(tài)Solid
顏色Light yellow to yellow
常見問題列表
生物活性
Pyrantel tartrate，一種四氫嘧啶光譜驅(qū)蟲藥，是煙堿乙酰膽堿受體 (nAChR) 激動劑。Pyrantel tartrate 可引起寄生蟲的痙攣性肌肉麻痹。Pyrantel tartrate 可用于胃腸道線蟲感染的研究。體外研究
Pyrantel induces
Ascaris suum
muscle contraction, with a pEC
50
of 7.24.
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle.
Pyrantel (72 h) inhibits the survival of
Ancylostoma ceylanicum
,
Necator americanus
and
Trichuris muris
on the third-stage larvae (IC
50
s=90.9, 2.0, and 95.5 μg/mL, respectively) and adult worms (IC
50
s=>100, 7.6, and 34.1 μg/mL, respectively).
體內(nèi)研究
Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.