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31828-68-9

中文名稱 L-高胱氨酸硫內(nèi)酯鹽酸鹽
英文名稱 L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
CAS 31828-68-9
分子式 C4H8ClNOS
分子量 153.63
MOL 文件 31828-68-9.mol
更新日期 2024/11/02 12:28:20
31828-68-9 結(jié)構(gòu)式 31828-68-9 結(jié)構(gòu)式

基本信息

中文別名
高半胱氨酸硫內(nèi)酯
L-高胱氨酸硫內(nèi)酯鹽酸鹽
L-高半胱氨酸硫內(nèi)酯鹽酸鹽
英文別名
H-HOCYS-THIOLACTONE HCL
L-HOMOCYSTEINETHIOLACTONEHCL
-3-Aminodihydrothiophen-2(3H)
L-HOMOCYSTEINE THIOLACTONE HCL*CRYST
L-HOMOCYSTEINETHILOACTONEHYDROCHLORIDE
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
L-HOMOCYSTEINE THIOLACTONE HCL*CRYSTALLI NE
(S)-3-aminodihydrothiophen-2(3H)-one hydrochloride
CAindexname:2(3H)-Thiophenone,3-aminodihydro-,hydr
(S)-3-Aminodihydro-2(3H)-thiophenone hydrochloride
所屬類別
生物化工:半胱氨酸類衍生物

物理化學(xué)性質(zhì)

熔點185-191 °C
儲存條件2-8°C
溶解度可溶于酸性水溶液(少許)、DMSO(少許)、水(少許)
形態(tài)固體
顏色淺米色
BRN3911455

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
安全說明22-24/25
WGK Germany3
L-高胱氨酸硫內(nèi)酯鹽酸鹽價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-101404AL-高胱氨酸硫內(nèi)酯鹽酸鹽
L-Homocysteine thiolactone hydrochloride
31828-68-910mg240元
2024/11/08HY-101404AL-高胱氨酸硫內(nèi)酯鹽酸鹽
L-Homocysteine thiolactone hydrochloride
31828-68-910mM * 1mLin Water264元
2024/11/08HY-101404AL-高胱氨酸硫內(nèi)酯鹽酸鹽
L-Homocysteine thiolactone hydrochloride
31828-68-925 mg480元

常見問題列表

生物活性
L-Homocysteine thiolactone hydrochloride是同型半胱氨酸的分子內(nèi)硫酯; 防止同型半胱氨酸轉(zhuǎn)化成蛋白質(zhì)。
體外研究

In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. This conversion occurs in all human cell types, including endothelial cells. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release.

體內(nèi)研究

Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer’s disease. Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent.

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