307297-40-1
中文名稱
Epitalon acetate
英文名稱
Epitalon
CAS
307297-40-1
分子式
C16H26N4O11
分子量
450.4
MOL 文件
307297-40-1.mol
更新日期
2025/01/03 11:29:54
307297-40-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMF: 1mg/mL; DMSO: 3mg/mL; PBS (pH 7.2): 5mg/mL
形態(tài)固體
InChIKeyJZJOFRXDMYAPDF-UQHDSAJHNA-N
SMILESC(=O)(O)C.[C@H](CC(=O)O)(C(=O)NCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)C |&1:4,19,28,r|
應(yīng)用領(lǐng)域
用途一
Epitalon is a synthetic tetrapeptide with anti-aging properties. Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates. Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice. It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice. Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.