3039-71-2
中文名稱
U 18666A
英文名稱
U 18666A
CAS
3039-71-2
分子式
C25H42ClNO2
分子量
424.06
MOL 文件
3039-71-2.mol
更新日期
2024/12/23 10:32:56
3039-71-2 結(jié)構(gòu)式
基本信息
中文別名
化合物U18666A(3b)-3-[2-(二乙基氨基)乙氧基]-雄甾-5-烯-17-酮鹽酸鹽
英文別名
U 18666AU18666A,HCl
U18666A - CAS 3039-71-2 - Calbiochem
3BETA-(2-DIETHYLAMINOETHOXY)-ANDROSTENONE HCL
3BETA-(2-DIETHYLAMINOETHOXY)ANDROST-5-EN-17 ONE, HCL
3BETA-(2-DIETHYLAMINO-ETHOXY)ANDROSTENONE HYDROCHLORIDE
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-onehydrochloride
(3B)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE HYDROCHLORIDE
(3β)-3-[2-(diethylamino)ethoxy]androst-5-en-17-one dihydrochloride
(3BETA)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE DIHYDROCHLORIDE
物理化學(xué)性質(zhì)
熔點(diǎn)195-196.5 °C(lit.)
熔點(diǎn)195-196.5 °C(lit.)
儲(chǔ)存條件2-8°C
儲(chǔ)存條件2-8°C
溶解度H2O: 9 mg/mL at ≤60 °C
溶解度H2O: 9 mg/mL at ≤60 °C
形態(tài)crystalline
顏色white
水溶解性Soluble in water at 10mg/ml
穩(wěn)定性從購(gòu)買之日起 2 年內(nèi)保持穩(wěn)定。 DMSO 或蒸餾水中的溶液可在 -20°C 下保存長(zhǎng)達(dá) 1 周。
常見(jiàn)問(wèn)題列表
生物活性
U18666A (U18) 是一種 intra-cellular cholesterol transport 的抑制劑，可抑制登革熱病毒的侵入和復(fù)制。靶點(diǎn)
Cholesterol.
體外研究
U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication.