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303-97-9

中文名稱 輔酶Q9
英文名稱 COENZYME Q9
CAS 303-97-9
分子式 C54H82O4
分子量 795.23
MOL 文件 303-97-9.mol
更新日期 2024/12/13 09:48:58
303-97-9 結(jié)構(gòu)式 303-97-9 結(jié)構(gòu)式

基本信息

中文別名
輔酶Q9
泛醌-9
泛醌-45
輔酶Q10雜質(zhì)
輔酶Q9(標(biāo)準(zhǔn)品)
癸利酮雜質(zhì)1(輔酶Q9)
英文別名
Q-9
CoQ9
coq(sub9)
NSC 226993
COENZYME Q9
UBIQUINONE-9
UBIQUINONE-45
Ubiquinone Q9
coenzymeq(sub9)
Q-9,Ubiquinone-9

物理化學(xué)性質(zhì)

熔點41-43°C
沸點826.8±65.0 °C(Predicted)
密度0.97±0.1 g/cm3(Predicted)
儲存條件−20°C
溶解度可溶于氯仿(輕微)、乙酸乙酯(輕微)、甲醇(輕微、加熱)
形態(tài)neat
顏色黃色到橙色
BRN1900081
穩(wěn)定性感光

安全數(shù)據(jù)

安全說明22-24/25
WGK Germany2
RTECS號DK4786000
海關(guān)編碼29146990
毒性LD50 oral in rat: > 4gm/kg
輔酶Q9價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/11XW30397902輔酶Q9303-97-925MG2967元
2024/11/11XW30397901輔酶Q9303-97-95MG941元
2024/11/08HY-101415輔酶Q9
Coenzyme Q9
303-97-91mg550元

常見問題列表

生物活性
Coenzyme Q9 (Ubiquinone Q9) 是嚙齒類動物泛醌的主要形式,是電子傳遞鏈中的一種雙親分子組分,具有內(nèi)源性抗氧化劑的作用。Coenzyme Q9 可減輕糖尿病引起的抗氧化防御機(jī)制的下降。Coenzyme Q9 改善左心室功能,減少心肌梗死面積和心肌細(xì)胞凋亡。
靶點

Human Endogenous Metabolite

體內(nèi)研究

Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury.
CoQ 10 and CoQ 9 are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ 10 , whereas CoQ 9 has been found in high concentrations in corn oil.
The lack of a functional CoQ 9 protein in homozygous CoQ 9 mutant (CoQ 9 (X/X)) mice causes a severe reduction in the CoQ 7 protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ 9 (X/X) mice that consequently die between 3 and 6 months of age.

Animal Model: Male Hartley guinea pigs of about 350-400 g body weight
Dosage: 5 mg/kg of body weight
Administration: P.o.; once a day for 4 weeks
Result: Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10.
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