303-45-7
303-45-7 結(jié)構(gòu)式
基本信息
棉子醇
棉子酚
棉籽酚
醋酸棉籽酚
棉酚溶液標(biāo)準(zhǔn)物質(zhì)
棉酚, 來(lái)源于棉花籽
GOSSYPOL
Thespesin
NSC 56817
NSC 624336
GOSSYPOL(P)
Gossypol solution
TIMTEC-BB SBB012338
3’-dimethyl-sopropyl-
GOSSYPOL, COTTON SEEDS
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
棉酚（gossypol），又稱棉毒素或棉籽醇，是棉屬植物體內(nèi)形成的一種黃色多酚二萘化合物。
| Target | Value |
|
Bcl-xL
(Cell-free assay) | 0.4 μM |
|
3α-hydroxysteroid dehydrogenase
(Cell-free assay) | 0.52 μM |
|
5α-reductase 1
(Cell-free assay) | 3.33 μM |
|
Bcl-2
(Cell-free assay) | 10 μM |
Gossypol, a natural product isolated from cottonseeds and roots that has been studied as an anticancer agent. The racemic form of Gossypol [(±)-Gossypol] is tested in several clinical trials and is well tolerated. The racemic form Gossypol ((±)-Gossypol) binds to Bcl-xL protein with a K i of 0.5 to 0.6 μM. (±)-Gossypol also potently binds to Bcl-2 protein with a K i value of 0.2-0.3 mM. The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (+)-Gossypol enantiomers. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001).