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30199-26-9

中文名稱 (R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚
英文名稱 XANTHORRHIZOL
CAS 30199-26-9
分子式 C15H22O
分子量 218.33
MOL 文件 30199-26-9.mol
30199-26-9 結(jié)構(gòu)式 30199-26-9 結(jié)構(gòu)式

基本信息

中文別名
(R)-5-(1,5-二甲基-4-己烯基)-鄰甲酚
英文別名
XANTHORRHIZOL
(R)-Xanthorrizol
Einecs 250-090-2
(-)-Xanthorrizol
XANTHORRHIZOL(RG)
(R)-(-)-Xanthorrhizol
(R)-5-(1,5-dimethyl-4-hexenyl)-o-cresol
Xanthorrhizol from Cucuma xanthorrhiza
5-(1,5-Dimethyl-4-hexenyl)-2-methylphenol
o-Cresol, 5-(1,5-dimethyl-4-hexenyl)-, (-)-

物理化學(xué)性質(zhì)

沸點(diǎn)326.9±11.0 °C(Predicted)
密度0.948±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度可溶于氯仿(少許)、乙酸乙酯(少許)、甲醇(少許)
酸度系數(shù)(pKa)10.34±0.10(Predicted)
形態(tài)無色至淡黃色油狀物。
顏色淡黃色至淡黃色
LogP5.480

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS07
警示詞危險(xiǎn)
危險(xiǎn)性描述H335-H319-H360-H315
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼60
安全說明53-36/37/39-45

常見問題列表

生物活性
Xanthorrhizol 是從 Curcuma xanthorrhiza 中分離出來的,一種有效的抗菌劑。
體外研究

Xanthorrhizol is a potential antibacterial agent from Curcuma xanthorrhiza against streptocpccus mutants. SEM analysis shows that, treatment of Candida species with MIC of Xanthorrhizol affects the external morphology of these yeasts. Cells incubated in the presence of Xanthorrhizol demonstrate a greater tendency to clump compared with the control cultures. Xanthorrhizol treated C. glabrata cells shows minor abnormalities without a smooth or a slightly awkward surface. Xanthorrhizol-treated Candida cells exhibit deformation and protrusions on the cell surface, which is more clearly demonstrated with C. guilliermondii and C. parapsilosis . In general, Candida exposed to, Xanthorrhizol at concentrations 1 x MICs exhibits substantial ultrastructural abnormalities such as shape deformation, protrusion, rugged cells surface, and clumping.

體內(nèi)研究

Ear edema induced by the topical application of TPA is suppressed by pre-treatment with Xanthorrhizol in a doserelated manner (P<0.005). Topical application of Xanthorrhizol alone does not induce ear edema in mice. All the mice treated with 7.5 nM TPA for 19 weeks after initiation by DMBA developed an average of 15.5±2.3 skin tumors per mouse (tumor multiplicity). Pre-treatment with 2 and 6 μM Xanthorrhizol reduces tumor multiplicity to 6.9±1.1 (P<0.005) and 4.0±1.1 (P<0.005), respectively, at 19 weeks. In addition, Xanthorrhizol at 2 and 6 μM dose dependently lowers the percentage of tumor-bearing mice (tumor incidence) to 80 and 57%, respectively, at the termination of the experiments. Furthermore, the tumor multiplicity (P<0.05) and incidence are reduced in the DMBA-initiated mice that are topically treated with Xanthorrhizol for 6 weeks after the induction of papillomas with hyperplasia, mild dysplasia and moderate dysplasia by topical TPA application for 6, 18 and 24 weeks, respectively. The increased ODC expression in mouse epidermis with acute inflammation and tumor promotion induced by TPA is inhibited by pre-treatment with Xanthorrhizol in a dose-dependent manner. The topical application of Xanthorrhizol after the induction of papillomas with hyperplasia and dysplasia also potently inhibited ODC expression.

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