300816-15-3
300816-15-3 結(jié)構(gòu)式
基本信息
6-甲基-1'-[2-(5-甲基-2-苯基-4-惡唑基)乙基]螺[4H-3,1-苯并惡嗪-4,4'-哌啶]-2(1H)-酮
6-甲基-1'-(2-(5-甲基-2-苯基惡唑-4-基)乙基)螺[苯并[D][1,3]惡嗪-4,4'-哌啶]-2(1H)-酮
6-甲基-1'-[2-(5-甲基-2-苯基-噁唑-4-基)乙基]-螺[4H-3,1-苯并噁嗪-4,4'-哌啶]-2(1H)-酮
6 - 甲基-1,1' - [2 - (5 - 甲基- 2-苯基- 4-惡唑基)乙基] - 螺[4H - 3-1,1 - 苯并惡嗪- 4,4' -哌啶]-2(1H)-酮
RS-504393
RS504393
RS504393 >=98% (HPLC)
6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidi
6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]
6-Methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro-[benzo[d][1,3]oxazine-4,4'-piperidin]-2(
6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
6-Methyl-1'-(2-(5-Methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 6-Methyl-1'-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]-
常見問題列表
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CCR2 89 nM (IC 50 ) |
Human α 1a receptor 72 nM (IC 50 ) |
Human α 1d receptor 460 nM (IC 50 ) |
5HT-1a receptor 1070 nM (IC 50 ) |
RS 504393 inhibits the MCP-1-induced chemotaxis with an IC 50 of 330 nM. RS 504393 treatment suppresses allergen induced β-hexosaminidase release significantly. Without allergen priming, MCP-1 induces mast cell degranulation, which is completely suppressed by RS 504393.
RS504393 (0.3-3 μg) with CCL2 progressively blocks thermal hyperalgesia dose-dependently in mice. RS 504393 (5?mg/kg, i.v.) supresses the elevated numbers of leukocytes and increased total protein content in BALF induced by The LPS. RS504393 significantly down regulates the LPS-induced elevation of IL-1β, PAI-1 mRNA and protein expressions. RS504393 significantly suppresses induced lung edema, protein-rich fluid, polymorphonuclear accumulation and bronchial wall thickening induced by LPS. RS-504393 significantly reduces renal pathology, especially the extensive interstitial fibrosis mediated by decrease in type I collagen synthesis in a UUO model.