300-84-5
300-84-5 結(jié)構(gòu)式
基本信息
亞?；撬?/span>
2-AMINOETHANESULFUNIC ACID
2-AMINOETHYLSULFINIC ACID
HYPOTAURINE
hypotaurine crystalline
Ethanesulfinic acid, 2-amino-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
亞牛磺酸是?；撬岬那绑w之一，經(jīng)過氧化變?yōu)榕；撬幔溉閯?dòng)物主要通過這條途徑合成，而合成牛磺酸的氧化酶是一個(gè)非限速的，所以可以保持一個(gè)平衡。晶體的溶解度只有6－7％，亞?；撬徕c要高一些。
自1975年Hayes等報(bào)道，缺乏?；撬釙?huì)導(dǎo)致幼貓視功能減退甚至失明后，人們對(duì)?；撬岬臓I(yíng)養(yǎng)作用越來越關(guān)注。
先在發(fā)現(xiàn)的牛磺酸功能很多，但主要是促進(jìn)細(xì)胞膜對(duì)糖的吸收，此外還可作用于胰島素受體，發(fā)揮胰島素樣效應(yīng)。
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Human Endogenous Metabolite
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Hypotaurine and taurine are found to reside within the cytosolic compartment of the cell. The ratio of taurine to hypotaurine is approx 50:1. The cytosolic concentration of taurine is approx. 50 mM. The concentration of hypotaurine decreases by 80% when resting neutrophils are converted into actively respiring cells by exposure to opsonized zymosan. Hypotaurine activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads to the activation of hypoxia signaling as well as to the enhancement of glioma cell proliferation and invasion.
Hypotaurine has antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviates mechanical allodynia and thermal hyperalgesia. Intrathecal hypotaurine suppresses acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord.