287194-41-6
中文名稱
287194-41-6
英文名稱
(+)-DHMEQ
CAS
287194-41-6
分子式
C13H11NO5
分子量
261.23
MOL 文件
287194-41-6.mol
更新日期
2024/12/03 15:40:32
287194-41-6 結(jié)構(gòu)式
基本信息
中文別名
(+)-DHMEQ2-羥基-N-[(1R,2R,6R)-2-羥基-5-氧代-7-氧雜雙環(huán)[4.1.0]庚-3-烯-3-基]苯甲酰胺
英文別名
(1R,2R,6R)-DHMEQ(1R,2R,6R)-Dehydroxymethylepoxyquinomicin
2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-
物理化學(xué)性質(zhì)
熔點(diǎn)184 °C
沸點(diǎn)617.2±55.0 °C(Predicted)
密度1.58±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : ≥ 35 mg/mL (133.98 mM)
酸度系數(shù)(pKa)8.43±0.30(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
(+)-DHMEQ 是一種抗氧化轉(zhuǎn)錄因子 Nrf2 的激活劑。(+)-DHMEQ 是 (-)-DHMEQ 的對(duì)映體。(+)-DHMEQ 抑制 NF-kB 的活性低于(-)-DHMEQ。靶點(diǎn)
Nrf2
體外研究
(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.