278605-15-5
中文名稱(chēng)
4-乙炔基-L-苯丙氨酸 HCL
英文名稱(chēng)
4-Ethynyl-L-phenylalanine HCl
CAS
278605-15-5
分子式
C11H11NO2
分子量
189.21
MOL 文件
278605-15-5.mol
278605-15-5 結(jié)構(gòu)式
基本信息
中文別名
4-乙炔基-L-苯丙氨酸 HCL 英文別名
4-Ethynyl-L-phenylalanineL-Phenylalanine, 4-ethynyl-
4-Ethynyl-L-phenylalanine HCl
所屬類(lèi)別
生物化工：丙氨酸類(lèi)衍生物物理化學(xué)性質(zhì)
沸點(diǎn)343.2±37.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 2.22 mg/mL (11.73 mM)
酸度系數(shù)(pKa)2.18±0.10(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
常見(jiàn)問(wèn)題列表
生物活性
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一種高效、選擇性的，可逆、競(jìng)爭(zhēng)性的色氨酸羥化酶 (TPH) 抑制劑，其 Ki 值為 32.6 μM。靶點(diǎn)
Ki: 32.6 μM (TPH)
體外研究
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
體內(nèi)研究
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.
| Animal Model: | Male Sprague-Dawley rats (200 g) |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |