270076-60-3
中文名稱
普那霉素
英文名稱
Pristinamycin
CAS
270076-60-3
分子式
C45H54N8O10
更新日期
2024/12/26 14:09:44
常見問題列表
生物活性
Pristinamycin 是一種具有口服活性的鏈霉素樣的抗生素，產(chǎn)生于 Streptomyces pristinaespiralis，Pristinamycin 由兩種化學(xué)上不相關(guān)的成分組成：Pristinamycin I (PI) 和 Pristinamycin II (PII)。Pristinamycin 對(duì)多種抗生素耐藥病原菌，特別是革蘭氏陽性菌，包括耐甲氧西林金黃色葡萄球菌 (MRSA)、萬古霉素耐藥金黃色葡萄球菌 (VRSA) 和糞腸球菌 (VREF) 具有高度的活性。體外研究
In-vitro studies show pristinamycin to inhibit Staphylococci and Streptococci , including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l.
體內(nèi)研究
To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage.