26988-72-7
中文名稱
1-甲基-色氨酸
英文名稱
1-METHYL-DL-TRYPTOPHAN
CAS
26988-72-7
分子式
C12H14N2O2
分子量
218.25
MOL 文件
26988-72-7.mol
更新日期
2024/11/28 09:55:18
26988-72-7 結(jié)構(gòu)式
基本信息
中文別名
1-甲基-色氨酸甲基-L-色氨酸
1-甲基-DL-色氨酸
2-氨基-3-(1-甲基-1H-吲哚-3-基)丙酸
英文別名
Me-L-Trp(Rac)-Indoximod
Tryptophan, 1-methyl-
N-Methyl-DL-tryptophan
1-METHYL-DL-TRYPTOPHAN
1-Methyl-DL-tryptophan 97%
1-METHYL-DL-TRYPTOPHAN USP/EP/BP
(2R)-2-ammonio-3-(1-methyl-3-indolyl)propanoate
2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
rac-(R*)-2-(1-Methyl-1H-indole-3-ylmethyl)glycine
所屬類別
生物化工：色氨酸類衍生物物理化學(xué)性質(zhì)
熔點250 °C (dec.)(lit.)
沸點429.3±35.0 °C(Predicted)
密度1.28±0.1 g/cm3(Predicted)
儲存條件Sealed in dry,2-8°C
酸度系數(shù)(pKa)2.26±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-雙加氧酶 (IDO) 抑制劑。(Rac)-Indoximod 和 IFN-γ 聯(lián)用顯著降低了表達 α-SMA 的人心肌成纖維細胞活性，并通過上調(diào) IRF-1，F(xiàn)as 和 FasL 基因誘導(dǎo)凋亡(apoptosis)。靶點
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IDO
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體外研究
(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion.
Cell Viability Assay
| Cell Line: | Human cardiac myofibroblasts (hCMs) |
| Concentration: | 0.5 mM |
| Incubation Time: | 3 days |
| Result: | Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3. |