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251456-60-7

中文名稱 4-(二甲氨基)-N-[7-(羥基氨基)-7-氧庚]苯甲酰胺
英文名稱 M344
CAS 251456-60-7
分子式 C16H25N3O3
分子量 307.39
MOL 文件 251456-60-7.mol
更新日期 2024/12/15 19:35:15
251456-60-7 結(jié)構(gòu)式 251456-60-7 結(jié)構(gòu)式

基本信息

中文別名
組蛋白去乙?;敢种苿?M 344)
4-二甲基氨基-N-(6-羥基氨基甲酰己基)苯甲酰胺
4-(二甲氨基)-N-[7-(羥基氨基)-7-氧庚]苯甲酰胺
化合物HISTONE DEACETYLASE INHIBITOR III
4-(二甲氨基)-N-[7-(羥基氨基)-7-氧庚]苯甲酰胺(組蛋白去乙?;敢种苿?
英文別名
M344
CS-661
MS 344
MS 344, D237
M344 (D 237)
M344 USP/EP/BP
M 344 (enzyme inhibitor)
HISTONE DEACETYLASE INHIBITOR III
Histone Deacetylase Inhibitor III(M344)
N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE
所屬類別
生物化工:HDAC 抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)161℃
儲(chǔ)存條件2-8°C
溶解度DMSO:可溶10mg/mL,澄清
形態(tài)白色固體
顏色白色至米色
敏感性感光
CAS 數(shù)據(jù)庫(kù)251456-60-7

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
WGK Germany3
海關(guān)編碼2928.00.2500
4-(二甲氨基)-N-[7-(羥基氨基)-7-氧庚]苯甲酰胺價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-135064-(二甲氨基)-N-[7-(羥基氨基)-7-氧庚]苯甲酰胺
M344
251456-60-75mg810元
2024/11/08HY-135064-(二甲氨基)-N-[7-(羥基氨基)-7-氧庚]苯甲酰胺
M344
251456-60-710mM * 1mLin DMSO891元
2024/11/08HY-135064-(二甲氨基)-N-[7-(羥基氨基)-7-氧庚]苯甲酰胺
M344
251456-60-710mg1265元

常見(jiàn)問(wèn)題列表

生物活性
M344 (D 237) 是一種組蛋白去乙?;敢种苿?,IC50 為 100 nM。
靶點(diǎn)

HDAC

100 nM (IC 50 )

體外研究

M344 is a potential histone deacetylase (HDAC) inhibitor. BRCA1 mRNA levels are determined by RT-PCR following exposure to increasing concentrations of the HDAC inhibitor M344 alone and in combination with Cisplatin in all 6 cell lines evaluated in this study. With increasing concentrations of M344, there is a dose dependant decrease in BRCA1 mRNA and treatment with both 1 and 5 μM concentrations of M344 resulting in a significant decrease in BRCA1 expression in all cell lines examined. M344 in combination with Cisplatin leads to a decrease in BRCA1 mRNA expression as compared to Cisplatin treatment alone in all cell lines with the exception of A2780s, which is recognized as having potent cytotoxicity to Cisplatin. In the MCF7 cell line, BRCA1 is down regulated at physiological doses of M344 (0.5 μM and 1 μM) but M344 does not have the same inhibitory effect on BRCA1 at the 5.0 μM dose. Co-treatment with Cisplatin and increasing concentrations of M344 reduces BRCA1 protein levels in all breast and ovarian cell lines examined.

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