223104-29-8
223104-29-8 結構式
基本信息
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺
SEA-0400
SEA 0400
SEA-0400
SEA0400 >=98% (HPLC)
SEA 0400
SEA-0400
SEA0400
2-(4-((2,5-DIFLUOROBENZYL)OXY)PHENOXY)-5-ETHOXYANILINE
2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
BenzenaMine, 2-[4-[(2,5-difluorophenyl)Methoxy]phenoxy]-5-ethoxy-
物理化學性質
常見問題列表
| Target | Value |
|
p38 MAPK
() | |
|
ERK
() | |
|
ROS
() | |
|
NCX
(in cultured astrocytes) | 5.0 nM |
|
NCX
(in cultured microglia) | 8.3 nM |
SEA0400 inhibits Na + -dependent 45 Ca 2+ uptake in cultured neurons, astrocytes, and microglia. IC 50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca 2+ -dependent manner.
SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.