| Identification | Back Directory | [Name]
SEA-0400 | [CAS]
223104-29-8 | [Synonyms]
CS-1043
SEA-0400
SEA 0400; SEA-0400
SEA0400 >=98% (HPLC)
SEA 0400; SEA-0400;SEA0400
2-(4-((2,5-DIFLUOROBENZYL)OXY)PHENOXY)-5-ETHOXYANILINE
2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
BenzenaMine, 2-[4-[(2,5-difluorophenyl)Methoxy]phenoxy]-5-ethoxy- | [Molecular Formula]
C21H19F2NO3 | [MDL Number]
MFCD07772188 | [MOL File]
223104-29-8.mol | [Molecular Weight]
371.38 |
| Chemical Properties | Back Directory | [Boiling point ]
485.0±45.0 °C(Predicted) | [density ]
1.254±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
insoluble in H2O; ≥18.57 mg/mL in DMSO; ≥46.4 mg/mL in EtOH with ultrasonic | [form ]
solid | [pka]
4.04±0.10(Predicted) | [color ]
White to khaki |
| Hazard Information | Back Directory | [Description]
SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).1 It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson''s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.2,3 | [Uses]
SEA 0400 is a novel and selective inhibitor of Na+-Ca2+ exchanger. | [target]
Na+-Ca2+ exchanger | [storage]
Store at -20°C |
|
|