22189-32-8
基本信息
壯觀霉素鹽酸鹽
壯觀霉素1GM
奇放線霉素鹽酸鹽
壯觀霉素(標(biāo)準(zhǔn)品)
鹽酸大觀霉素,五水
鹽酸壯觀霉素五水合物
壯觀霉素鹽酸鹽水合物
大觀霉素鹽酸鹽水合物
鹽酸大觀霉素五水合物
D00869
U-18409AE
spectogard
Trobicin (tn)
SPECTINOMYCIN HCL
SPECTINOMYCIN 2HCL
Spectinomycin,≥98%
Spectinomycin HCL USP/BP
Spectinomycin dihydrochL
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
應(yīng)用領(lǐng)域
常見問題列表
Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli . When added to an exponentially growing culture, spectinomycin (50 μg/mL) rapidly and reversibly inhibits growth of Escherichia coli . Amino acid incorporation is slowed immediately but RNA synthesis continued. In extracts of Escherichia coli B, spectinomycin inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA. Maximum inhibition (70 to 80%) is achieved at 1 μg/mL (3 μM). . Spectinomycin blocks the translocation of peptidyl-tRNAs from the A-site to the P-site by inhibiting the binding of elongation factor G to the ribosome. Spectinomycin interacts specifically with the residues G1064 and 01192 in 16S rRNA and potentially change this molecule into an inactive conformation. Spectinomycin acts as a mixed noncompetitive inhibitor for the td intron RNA with a K i of 7.2 mM. The splicing inhibition by spectinomycin is dependent on pH changes and Mg 2+ concentration, indicating electrostatic interactions with the intron RNA.
Renal excretion is a major elimination pathway for spectinomycin. Following IV administration, approximately 55% of the drug is excreted into the urine in unchanged form. After IV administration of 10 mg/kg spectinomycin shows a peak plasma concentration of 37.8 μg/mL and a systemic exposure (area-under the curve AUC 0-∞ ) of 15.7 μg/mL. Following single dose intramuscular administration, the overall elimination half-life of spectinomycin is 1.2 h in cattle, 1.0 h in sheep, 1.0 h in pigs, 1.65 h in chicken and 1.85 h in humans.