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189261-10-7

中文名稱 那他珠單抗
英文名稱 Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer
CAS 189261-10-7
分子式 C40H55N7O11S
分子量 841.97
MOL 文件 189261-10-7.mol
更新日期 2024/12/20 13:38:27
189261-10-7 結(jié)構(gòu)式 189261-10-7 結(jié)構(gòu)式

基本信息

中文別名
NATALIZUMAB ( 那他珠單抗 )
英文別名
Natalizumab-Tysabri
Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer

物理化學(xué)性質(zhì)

儲(chǔ)存條件Store at 4°C, do not freeze
形態(tài)Liquid
顏色Colorless to light yellow

安全數(shù)據(jù)

毒害物質(zhì)數(shù)據(jù)189261-10-7(Hazardous Substances Data)

常見問(wèn)題列表

生物活性
Natalizumab 是一種重組的人源化單克隆抗體,與 α4β1-整聯(lián)蛋白 (α4β1-integrin) 結(jié)合并阻斷其與血管細(xì)胞粘附分子 1 (VCAM-1) 的相互作用。Natalizumab 可用于復(fù)發(fā)緩解型多發(fā)性硬化癥和克羅恩氏病的研究。Natalizumab 也可阻止淋巴細(xì)胞進(jìn)入中樞神經(jīng)系統(tǒng),從而防止急性脫髓鞘復(fù)發(fā)。
體外研究

Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.

體內(nèi)研究

Natalizumab binds rapidly and with high affinity to α4-integrin. Maximal binding (≥80% saturation), measured in vitro on isolated lymphocyte membranes, occurred 24 hours after intravenous (IV) doses of natalizumab 1 mg/kg to 6 mg/kg.

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