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188817-13-2

中文名稱 5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑
英文名稱 SC-560
CAS 188817-13-2
分子式 C17H12ClF3N2O
分子量 352.74
MOL 文件 188817-13-2.mol
更新日期 2024/12/23 17:38:57
188817-13-2 結(jié)構(gòu)式 188817-13-2 結(jié)構(gòu)式

基本信息

中文別名
化合物SC560
SC-560 SC-560
COX-1抑制劑(SC-560)
5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑
英文別名
SC SC
SC-560
CS-1042
5-(4-Chlorophenyl)
SC-560
SC 560
SC560
SC-560 Assay Reagent
SC-560 - CAS 188817-13-2 - Calbiochem
5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-TRIFLUOROMETHYLPYRAZOLE
5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole

物理化學性質(zhì)

熔點63 °C
沸點440.6±45.0 °C(Predicted)
密度1.33
儲存條件2-8°C
儲存條件2-8°C
溶解度二甲基亞砜:>20mg/mL
酸度系數(shù)(pKa)-3?+-.0.10(Predicted)
形態(tài)類白色固體
顏色白色至淺黃色至淺橙色

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H319-H335-H315
危險品標志Xi
危險類別碼36/37/38
安全說明26-36
WGK Germany3
WGK Germany3
海關(guān)編碼2933199090
5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-591055-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑
SC-560
188817-13-25mg566元
2024/11/08HY-591055-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑
SC-560
188817-13-210mM * 1mLin DMSO660元
2024/11/08HY-591055-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑
SC-560
188817-13-210mg1076元

常見問題列表

生物活性
SC-560 是一種高度選擇性的 COX-1 抑制劑,IC50值為9 nM,而對于 COX-2 的IC50值為6.3μM 比 COX-1 高近1,000倍。
靶點
TargetValue
COX-1
(Cell-free assay)
9 nM
COX-2
(Cell-free assay)
6.3 μM
體外研究

Preincubation of COX-1 with SC-560 inhibits the conversion of arachidonic acid to PGE2 in a concentration-dependent manner. The IC 50 of SC-560 for COX-2 is 6.3 μM, nearly 1,000-fold higher than with COX-1. SC-560 shows a dose and time dependent inhibitory effect on HCC cell growth. SC-560 also inhibits colony formation in soft agar and induces apoptosis in HCC cells in a dose-dependent manner. Moreover, SC-560 decreases the levels of the anti-apoptotic proteins survivin and XIAP and activates caspase 3 and 7 in a dose and time dependent fashion.

體內(nèi)研究

Oral dosing with either 10 or 30 mg/kg SC-560 1 hour before assay completely inhibits ionophore-stimulated TxB2production, indicating that SC-560 is orally bioavailable and inhibits COX-1 in vivo . SC-560 extensively distributes into rat tissues, and has a CL approaching hepatic plasma flow. The drug displays low less than 15% and formulation dependent bioavailability after oral administration and demonstrates kidney toxicity.

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