1781882-65-2
中文名稱
PYRIDOSTATIN HYDROCHLORIDE
英文名稱
Pyridostatin hydrochloride
CAS
1781882-65-2
分子式
C5H6ClNSn8
分子量
1065.24
MOL 文件
1781882-65-2.mol
更新日期
2025/01/12 17:59:21
1781882-65-2 結(jié)構(gòu)式
PYRIDOSTATIN HYDROCHLORIDE價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 5mg | 1120元 |
| 2024/11/08 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 10mM * 1mLin Water | 1268元 |
| 2024/11/08 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 10mg | 1480元 |
常見問題列表
生物活性
Pyridostatin (RR82) hydrochloride 是一種高選擇性的 G-quadruplex DNA 穩(wěn)定劑 (Kd=490 nM)。Pyridostatin hydrochloride 通過誘導(dǎo)復(fù)制和轉(zhuǎn)錄依賴的 DNA 損傷促進(jìn)人類癌細(xì)胞生長停滯。Pyridostatin hydrochloride 靶向原癌基因 Src。Pyridostatin hydrochloride 降低人乳腺癌細(xì)胞 SRC 蛋白水平和 SRC 依賴的細(xì)胞運(yùn)動。靶點
Kd: 490 nM (G-quadruplexe)
體外研究
Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest.
Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
Cell Viability Assay
| Cell Line: | Over 60 different cancer cell lines |
| Concentration: | 10 μM |
| Incubation Time: | 48 hours |
| Result: | Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines. |