17696-69-4
中文名稱
血卟啉二鹽酸鹽
英文名稱
HEMATOPORPHYRIN DIHYDROCHLORIDE
CAS
17696-69-4
分子式
C34H40Cl2N4O6
分子量
671.61
MOL 文件
17696-69-4.mol
更新日期
2024/12/23 10:19:41
17696-69-4 結(jié)構(gòu)式
基本信息
中文別名
鹽酸血紫質(zhì)鹽酸血紫素
血紫素鹽酸鹽
血卟啉鹽酸鹽
二鹽酸血紫素
血卟啉二鹽酸鹽
鹵代卟啉鹽酸鹽
一水合二鹽酸血卟啉
血卟啉IX二氯化氫
血卟啉鹽酸鹽(一水)
英文別名
ematoporfirinaHemaloporphyrin
HematoporphyrineDihcl
HAEMATOPORPHYRINDICHLORIDE
Haematopophyrin dihydrochloride
HEMATOPORPHYRIN DIHYDROCHLORIDE
HAEMATOPORPHYRIN DIHYDROCHLORIDE
HEMATOPORPHYRIN IX DIHYDROCHLORIDE
HAEMATOPORPHYRIN Dihydrochloride(RG)
HEMATOPORPHYRIN DIHYDROCHLORIDE USP/EP/BP
所屬類別
原料藥：抗抑郁、躁狂藥物理化學(xué)性質(zhì)
儲(chǔ)存條件2-8°C
溶解度DMSO (Slightly), Methanol (Slightly)
形態(tài)Solid
顏色Very Dark Red
水溶解性Insoluble in water. Soluble in pyridine (5%).
Merck14,4636
BRN78957
穩(wěn)定性Hygroscopic
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
危險(xiǎn)類別碼33
RTECS號(hào)TS5505000
TSCAYes
毒性mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978.
常見問題列表
應(yīng)用
有研究表明血卟啉二鹽酸鹽可用于制備具有高結(jié)晶速率的樹脂組合物，其包含聚呋喃二甲酸亞烷基酯(polyalkylenefurandicarboxylate)樹脂和卟啉化合物。該聚呋喃二甲酸亞烷基酯樹脂優(yōu)選為聚呋喃二甲酸亞丁基酯樹脂。該卟啉化合物優(yōu)選為血卟啉二鹽酸鹽(hematoporphyrindihydrochloride)。生物活性
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一種光敏劑，是血紅素結(jié)合蛋白親和色譜底物。當(dāng)暴露于紅光下時(shí)，Hematoporphyrin dihydrochloride 可以誘導(dǎo) U87 膠質(zhì)瘤細(xì)胞凋亡，并降低體內(nèi)腫瘤的生長(zhǎng)。體外研究
Hematoporphyrin (20-120 nM; 60 min) dose-dependently inhibits cell viability in U87 and U251 glioma cells, with IC
50
s of 85 and 166 nM, respectively.
Hematoporphyrin (85 nM; 60 min) induces cell apoptosis via induction of ROS in U87 cells.
Hematoporphyrin (85 nM; 60 min) induces morphological changes of U87 cells under the red light, including shrinking, fragmentation.
Cell Viability Assay
| Cell Line: | U87 and U251 cells |
| Concentration: | 20, 40, 60, 80, 100, 120 nM |
| Incubation Time: | 60 min |
| Result: |
Inhibited cell viability in a dose-dependent manner.
Was more effective under the red light than white light. |
Apoptosis Analysis
| Cell Line: | U87 cells |
| Concentration: | 85 nM |
| Incubation Time: | 60 min |
| Result: |
Induced apoptotic nuclei in U87 cells with low cell density.
Induced the ROS and decreased the mitochondrial membrane potential. |
體內(nèi)研究
Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels.
| Animal Model: | Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130 |
| Dosage: | 5, 10 mg/kg |
| Administration: | I.p. daily during the initial 10 days and biweekly for the next 2 months |
| Result: |
No tumor could be palpated a few days after exposure of the rats to light.
The skin healed completely and regrowth of the hair occurred. Massive coagulation necrosis of the tumor 24 h after phototreatment (×40). |