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164178-33-0

中文名稱 [6-碘-2-甲基-1-[2-(4-嗎啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮
英文名稱 AM 630
CAS 164178-33-0
分子式 C23H25IN2O3
分子量 504.36
MOL 文件 164178-33-0.mol
更新日期 2024/10/09 14:32:42
164178-33-0 結(jié)構(gòu)式 164178-33-0 結(jié)構(gòu)式

基本信息

中文別名
(6-碘-2-甲基-1-(2-嗎啉-4-基乙基)-1H-吲哚-3-基)(4-甲氧基苯基)甲酮
[6-碘-2-甲基-1-[2-(4-嗎啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮
英文別名
AM 630
CS-1545
AM630
AM 630
SC-200365(AM-630)
6-Iodopravadoline
AM630
AM 630
AM-630
Iodopravadoline (AM630)
1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole
(6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone
6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

沸點605.9±55.0 °C(Predicted)
密度1.49±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度二甲基亞砜:>5mg/mL
酸度系數(shù)(pKa)6.98±0.10(Predicted)
形態(tài)粉末
顏色白色至米色

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS09
警示詞警告
危險性描述H410
防范說明P273-P501
危險品標志N
危險類別碼50
安全說明61
危險品運輸編號UN 3077 9 / PGIII
WGK Germany3
[6-碘-2-甲基-1-[2-(4-嗎啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2023/03/20HY-15421[6-碘-2-甲基-1-[2-(4-嗎啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮
6-Iodopravadoline
164178-33-010mg1050元
2023/03/20HY-15421[6-碘-2-甲基-1-[2-(4-嗎啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮
6-Iodopravadoline
164178-33-010mM * 1mLin DMSO1155元
2023/03/20HY-15421[6-碘-2-甲基-1-[2-(4-嗎啉基)乙基]-1H-吲哚-3-基](4-甲氧基苯基)甲酮
6-Iodopravadoline
164178-33-050mg4100元

常見問題列表

生物活性
6-Iodopravadoline (AM630) 是一種選擇性的 CB2 拮抗劑,Ki 值為 31.2 nM,對其選擇性是對 CB1 受體的 165 倍。
靶點

Ki: 31.2 nM (CB 2 )

體外研究

The AM251 and 6-Iodopravadoline (AM630)-evoked Ca 2+ influxes into TG sensory neurons aere concentration-dependent, and fitted. The EC 50 for AM251 and 6-Iodopravadoline are 7.37 μM and 15.6 μM, respectively. AM251 and 6-Iodopravadoline activate TRPA1 in TG sensory neurons. 6-Iodopravadoline is comparable in value in both TRPA1 and TRPV1/TRPA1 expressing CHO cells (2 and 4.6 μM, respectively). AM251 and 6-Iodopravadoline activation of TRPA1 is modulated by TRPV1. 6-Iodopravadoline (0, 50, 100, and 200 nM) is not toxic to RAW264.7 cells. 6-Iodopravadoline (100 nM) substantially inhibits osteoclastogenesis in cultures with RANKL and Ti particles in a dose-dependent manner. 6-Iodopravadoline (1 μM) blocks the CP-55,940 dose response with EC 50 of 170 nM at human and EC 50 of 110 nM at rat cannabinoid CB2 receptor.

體內(nèi)研究

6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.) significantly reduces the time spent in the light box compared with vehicle group. 6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day) produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used.

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