| Identification | Back Directory | [Name]
AM 630 | [CAS]
164178-33-0 | [Synonyms]
AM 630
CS-1545
AM630;AM 630
SC-200365(AM-630)
6-Iodopravadoline
AM630;AM 630;AM-630
Iodopravadoline (AM630)
1-[2-(Morpholin-4-yl)ethyl]-2-Methyl-3-(4-Methoxybenzoyl)-6-iodoindole
(6-iodo-2-Methyl-1-(2-Morpholinoethyl)-1H-indol-3-yl)(4-Methoxyphenyl)Methanone
6-IODO-2-METHYL-1-[[2-(4-MORPHOLINYL)ETHYL]-1H-INDOL-3-YL](4-METHOXYPHENYL)METHANONE
Methanone, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)- | [Molecular Formula]
C23H25IN2O3 | [MDL Number]
MFCD01861183 | [MOL File]
164178-33-0.mol | [Molecular Weight]
504.36 |
| Chemical Properties | Back Directory | [Boiling point ]
605.9±55.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
powder | [pka]
6.98±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
AM 630 acts as a potential CB2 receptor cannabinoid antagonist with application towards human lung cancer treatment and angiogenesis induction. | [Definition]
ChEBI: [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-3-indolyl]-(4-methoxyphenyl)methanone is a N-acylindole. | [Biological Activity]
CB 2 antagonist/inverse agonist (K i = 31.2 nM) that displays 165-fold selectivity over CB 1 receptors. Behaves as a weak partial/inverse agonist at CB 1 receptors. | [Biochem/physiol Actions]
AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356). | [storage]
Desiccate at +4°C | [References]
1. ross r a, brockie h c, stevenson l a, et al. agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656 and am630. british journal of pharmacology, 1999, 126(3): 665-672. 2. patil m, patwardhan a, salas m m, et al. cannabinoid receptor antagonists am251 and am630 activate trpa1 in sensory neurons. neuropharmacology, 2011, 61(4): 778-788. |
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