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1576-37-0

中文名稱 N-芐基-對甲苯磺酸胺
英文名稱 BTS
CAS 1576-37-0
分子式 C14H15NO2S
MDL 編號 MFCD00159328
分子量 261.34
MOL 文件 1576-37-0.mol
更新日期 2024/12/18 13:15:43
1576-37-0 結(jié)構(gòu)式 1576-37-0 結(jié)構(gòu)式

基本信息

中文別名
N-芐基-對甲苯磺酸胺
英文別名
4-METHYL-N-(PHENYLMETHYL)BENZENESULFONAMIDE
BTS
LABOTEST-BB LT00786416
N-BENZYL-P-TOLUENESULFONAMIDE
N-BENZYL-P-TOLUENESULPHONAMIDE
4-methyl-n-(phenylmethyl)-benzenesulfonamid
n-benzyl-p-toluenesulfonamid
N-BENZYL-4-METHYL-BENZENESULFONAMIDE
N-Tosylbenzylamine
N-Methyl-N-(phenylmethyl)benzenesulfonamide
N-Tosylbenzenemethaneamine
N-Tosylphenylmethanamine
所屬類別
有機(jī)原料:酰胺類化合物

物理化學(xué)性質(zhì)

熔點(diǎn)115 °C
沸點(diǎn)419.1±48.0 °C(Predicted)
密度1.204±0.06 g/cm3(Predicted)
儲存條件Keep in dark place,Sealed in dry,Room Temperature
溶解度可溶于氯仿(少許)、可溶于二氯甲烷、乙酸乙酯(少許)
酸度系數(shù)(pKa)11.54±0.30(Predicted)
形態(tài)白色結(jié)晶固體
顏色白色至灰白色
敏感性感光
CAS 數(shù)據(jù)庫1576-37-0(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
RTECS號XT5490000
海關(guān)編碼2935.90.9500
毒性rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 41, 1953.

應(yīng)用領(lǐng)域

用途1
A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin鈥檚 interaction with F-actin. Does not affect platelet myosin II.

常見問題列表

生物活性
BTS (N-Benzyl-p-toluenesulfonamide) 是一種有效和選擇性的骨骼肌肌球蛋白 II 亞片段 1 (S1) ATPase 活性抑制劑,對肌動(dòng)蛋白和 Ca2+ 刺激的肌球蛋白 S1 ATPase 的 IC50 值約為 5 μM。BTS 可特異性抑制骨骼肌快速纖維的收縮。
靶點(diǎn)

IC50: ~5 μM (skeletal muscle myosin II S1 ATPase)

體外研究

BTS (2-12 μM) inhibits the Ca 2+ -stimulated ATPase activity of myosin S1 in the absence of actin, with an IC 50 of ~5 μM.
BTS (2-20 μM) reversibly inhibits the gliding motility rate of heavy meromyosin (HMM).
BTS (100 μM) releases myosin from actin in the presence of ADP.
BTS (0-20 μM) reversibly inhibits isometric Ca 2+ -activated tension in skinned skeletal muscle fibres from rabbit and frog, with IC 50 s of ~3 μM and 1 μM, respectively.

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