156-86-5
中文名稱
高精氨酸
英文名稱
Homoarginine
CAS
156-86-5
分子式
C7H16N4O2
MDL 編號(hào)
MFCD00237108
分子量
188.23
MOL 文件
156-86-5.mol
更新日期
2024/10/17 17:06:42
156-86-5 結(jié)構(gòu)式
基本信息
中文別名
高精氨酸類鳥氨酸
英文別名
H-HAR-OHH-HOARG-OH
H-HOMOARG-OH
HOMOARGININE
L-ALPHA-AMINO-EPSILON-GUANIDINOHEXANOIC ACID
L-HOMOARGININE
(S)-2-AMINO-6-GUANIDINOHEXANOIC ACID
l-lysin
l-n(sup6)-amidinolysine
n(sup6)-(aminoiminomethyl)-l-lysin
(2S)-2-amino-6-(diaminomethylideneamino)hexanoic acid
Homo-L-arginine
H-HOMOARGININE
L-LYSINE, N6-(AMINOIMINOMETHYL)-
N6-Amidino-L-lysine
所屬類別
生物化工：常見(jiàn)氨基酸及蛋白質(zhì)類物理化學(xué)性質(zhì)
熔點(diǎn)207-209 °C
沸點(diǎn)376.3±52.0 °C(Predicted)
密度1.39±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at RT.
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)2.52±0.24(Predicted)
形態(tài)Powder
顏色White to off-white
CAS 數(shù)據(jù)庫(kù)156-86-5(CAS DataBase Reference)
常見(jiàn)問(wèn)題列表
生物活性
H-HoArg-OH (L-Homoarginine) 是一種器官特異性、無(wú)競(jìng)爭(zhēng)性的血清“骨和肝”alkaline phosphatase 的抑制劑。靶點(diǎn)
| Target | Value |
|
alkaline phosphatase
() |
體外研究
It is found that H-HoArg-OH (L-homoarginine), a homologue of arginine, is a strong inhibitor of human bone and liver alkaline phosphatase while it has virtually no effect on intestinal and placental alkaline phosphatases unlike H-HoArg-OH which inhibits intestinal and placental alkaline phosphatases but not the liver and bone enzymes. These four tissues mentioned are the major contributors to the serum alkaline phosphatase. It is also indicated that low levels of the endogenous amino acid H-HoArg-OH are linked to cardiovascular disease.