1533426-72-0
中文名稱(chēng)
SCR7
英文名稱(chēng)
SCR7
CAS
1533426-72-0
分子式
C18H14N4OS
分子量
334.4
MOL 文件
1533426-72-0.mol
更新日期
2024/05/20 09:19:55
1533426-72-0 結(jié)構(gòu)式
基本信息
中文別名
2,3-二氫-5,6-二[(E)-(苯基亞甲基)氨基]-2-硫代-4(1H)-嘧啶酮 英文別名
SCR7CS-1733
SCR7 USP/EP/BP
5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol
5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
2,3-Dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-
所屬類(lèi)別
生物化工：DNA/RNA Synthesis 抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)206-208°C
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)7.93±0.25(Predicted)
形態(tài)固體
顏色淡黃色
常見(jiàn)問(wèn)題列表
生物活性
SCR7 是一種特異性 DNA Ligase IV 抑制劑，其阻斷非同源性末端連接(NHEJ)。體外研究
SCR7 effectively inhibits the formation of multimers at 200 μM and above. SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. SCR7 suppresses the NHEJ repair of CRISPR-Cas9-induced DSBs.體內(nèi)研究
SCR7 treatment (10 mg/kg, i.m.) signi?cantly reduces breast adenocarcinoma-induced tumor, and exhibits 4-fold increase in lifespan compared with control group. However, in Swiss albino mice with Dalton’s lymphoma tumor model, SCR7 (20 mg/kg, i.p.) exhibits neither tumor regression nor increase in lifespan. In BALB/c mice, SCR7 (20 mg/kg, i.p.) signi?cantly enhances the cytotoxic effects of radiation, etoposide and 3-Aminobenzamide on tumor derived from Dalton’s lymphoma (DLA) cells.