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151358-47-3

中文名稱 4(二(1H-吲哚-3-基)甲基)苯酚
英文名稱 4-(di(1H-indol-3-yl)Methyl)phenol
CAS 151358-47-3
分子式 C23H18N2O
分子量 338.4
MOL 文件 151358-47-3.mol
更新日期 2024/06/03 14:41:41
151358-47-3 結構式 151358-47-3 結構式

基本信息

中文別名
化合物DIM-C-PPHOH
4(二(1H-吲哚-3-基)甲基)苯酚
英文別名
C-DIM8
DIM-C-pPhOH
DIM-C-pPhOH(CDIM8)
4-(di(1H-indol-3-yl)Methyl)phenol
4-[bis(1H-indol-3-yl)methyl]phenol
Phenol, 4-(di-1H-indol-3-ylmethyl)-
1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane

物理化學性質

熔點122-124 °C
沸點610.2±50.0 °C(Predicted)
密度1.321±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
溶解度溶于 DMSO (35 mg/ml);乙醇(35 毫克/毫升)
酸度系數(shù)(pKa)9.98±0.26(Predicted)
形態(tài)固體
顏色粉色
穩(wěn)定性Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
4(二(1H-吲哚-3-基)甲基)苯酚價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/11/08HY-1120554(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH
151358-47-31mg500元
2024/11/08HY-1120554(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH
151358-47-35mg750元
2024/11/08HY-1120554(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH
151358-47-310mM * 1mLin DMSO825元

常見問題列表

生物活性
DIM-C-pPhOH (C-DIM8, CDIM8)是一種 nuclear receptor 4A1 (NR4A1)(Nur77) 拮抗劑。DIM-C-pPhOH 可抑制腫瘤生長和mTOR信號傳導,并誘導細胞凋亡和細胞應激。DIM-C-pPhOH 可降低細胞增殖,其對 ACHN細胞 和 786-O細胞 的IC50值分別為13.6 μM 和 13.0 μM。
靶點
TargetValue
Nur77
(786-O cells based assay)
13.0 μM
Nur77
(ACHN cells based assay)
13.6 μM
體外研究

DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.
DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.
DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.
DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.

Cell Proliferation Assay

Cell Line: ACHN and 786-O cells
Concentration: 7.5 μM, 15 μM, 20 μM
Incubation Time: 24 hours
Result: Significantly decreased cell proliferation.

Apoptosis Analysis

Cell Line: ACHN and 786-O cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Induced apoptosis in ACHN and 786-O cells.

Western Blot Analysis

Cell Line: ACHN and 786-O cells
Concentration: 15 μM, 20 μM
Incubation Time: 24 hours
Result: Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases.
體內研究

DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.

Animal Model: Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells
Dosage: 30 mg/kg/day
Administration: Oral gavage; daily; for 50 days
Result: Resulted in a significant inhibition of tumor growth.
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