145435-72-9
145435-72-9 結(jié)構(gòu)式
基本信息
(2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-Cmethyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
其化學(xué)名為13－［（2，6－二脫氧－3－C－甲基－3－O－甲基－ａ－L－吡喃核糖基）氧］－2－乙基－3，4，10－三脫氧3，5，8，10，12，14－六甲基－7－丙基－11－［［3，4，6－三脫氧－3－（二甲氨基）－b－D－吡喃木糖基］氧］－，（2R，3S，4R，5S,8R，10R，11R，12S，13S，14R）－1－氧雜－7－氮雜環(huán)－15－單環(huán)。外觀為白色至米黃色粉末，不溶于水，具有吸濕性，在高溫條件下穩(wěn)定，對(duì)光不敏感，重結(jié)晶后只有1種構(gòu)型。加米霉素在7α位上由單一丙基取代，該特殊結(jié)構(gòu)有利于其在生理pH值條件下被快速吸收，且在靶組織肺中可維持較長(zhǎng)作用時(shí)間。
圖1為加米霉素的結(jié)構(gòu)式
表1為加米霉素對(duì)牛呼吸系統(tǒng)疾病病原菌的體外抗菌活性
有關(guān)加米霉素的獸用抗生素、理化性質(zhì)、藥理作用、制備方法等是由Chemicalbook的丁紅編輯整理。（2016-04-25）
1.牛的應(yīng)用 用于治療敏感菌引起的牛呼吸系統(tǒng)疾病（BRD）。
2.羊的應(yīng)用 用于控制綿羊的腐蹄病及治療由鏈桿菌素引起的綿羊跛腳突發(fā)病。
MIC: 0.00012 μg/mL ( MmmSC strain B237), 0.00006μg/mL ( MmmSC strain Tan8)
The MIC values in serum are significantly lower than those in artificial medium; at an initial inoculum size of 10 6 cfu/mL, these are 64-, 8- and 64-fold lower for gamithromycin, tylosin and tilmicosin, respectively, against MmmSC strain B237 in serum compare to artificial medium. A similar pattern emerges for Tan8. Heat-inactivation of serum results in an MIC for gamithromycin that is higher than in either non-treated serum or artificial medium.
The proportion of foals that recover without the need for a change in treatment is significantly (P<0.048) higher for foals treated with Gamithromycin (GAM) (38 of 40; 95%) or AZM-RIF (39 of 40; 98%) compare to control foals (32 of 41; 78%). The clinical scores, number of abscesses and the abscess scores after 1 and 2 weeks of treatment are significantly lower for foals treated with Gamithromycin (GAM) or AZM-RIF compare to control foals. The WBC count of foals treated with Gamithromycin (GAM) is significantly higher than that of foals treated with AZM-RIF on week 3 of treatment.