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139298-40-1

中文名稱 N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽
英文名稱 KN-93
CAS 139298-40-1
分子式 C26H29ClN2O4S
MDL 編號 MFCD00236424
分子量 501.04
MOL 文件 139298-40-1.mol
更新日期 2024/12/20 09:35:50
139298-40-1 結(jié)構(gòu)式 139298-40-1 結(jié)構(gòu)式

基本信息

中文別名
神經(jīng)元CAMK-II抑制劑(KN-93)
(BASE),KN-93游離態(tài),鹽酸鹽,磷酸鹽各形式均有
CA2+/鈣調(diào)蛋白依賴性激酶Ⅱ(CA2+/CAM PKⅡ)競爭性抑制劑KN-3
N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽
N-[2-[[[3-(4-氯苯基)烯丙基](甲基)氨基]甲基]苯基]-N-(2-羥乙基)-4-甲氧基苯磺酰胺
N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 100MG
(E)-N-(2-(((3-(4-氯苯基)烯丙基)(甲基)氨基)甲基)苯基)-N-(2-羥乙基)-4-甲氧基苯磺酰胺
N-[2-[[[3-(4-氯苯基)-2-丙烯-1-基]甲基氨基]甲基]苯基]-N-(2-羥基乙基)-4-甲氧基苯磺酰胺
英文別名
KN-93
所屬類別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

密度1.288
儲(chǔ)存條件2-8°C
儲(chǔ)存條件2-8°C
溶解度DMSO: 1 mg/mL
溶解度在DMSO中的溶解度為1 毫克/毫升
形態(tài)類白色固體
顏色white
顏色白色
InChIKeyLLLQTDSSHZREGW-AATRIKPKSA-N
CAS 數(shù)據(jù)庫139298-40-1(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼20/21/22
危險(xiǎn)類別碼R20/21/22
安全說明22-24/25-36/37
安全說明S22-S24/25
WGK Germany3
WGK Germany3
海關(guān)編碼29299000
N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08S6787N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽
KN-93
139298-40-15mg1176.13元
2024/11/08S6787KN-93139298-40-110mM (1mL in DMSO)1531.53元
2024/11/08K0055KN-93
KN-93
139298-40-15mg415元

常見問題列表

生物活性
KN-93 是一種具有細(xì)胞滲透性和競爭性的 Ca2+/calmodulin-dependent protein kinase II (CaMK-II) 的可逆抑制劑,對于兔心肌 CaM 激酶活性的Ki值為2.58 μM。
靶點(diǎn)
TargetValue
CaMKII
(Cell-free assay)
2.58 μM(Ki)
體外研究

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. KN-93 (10 μM )significantly inhibits the activation of CaMKII/NF-κB signaling induced by elevated glucose, and subsequently decreases the expression of VEGF, iNOS and ICAM-1 in Müller cells.

體內(nèi)研究

KN-93 (1 mg/kg/day, i.p.) inhibits retinal vascular leakage induced by diabetes, and suppresses phosphorylation of CaMKII and NF-κB in diabetic retina.

"139298-40-1" 相關(guān)產(chǎn)品信息
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