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1366234-01-6

英文名稱(chēng) GSK503A)
CAS 1366234-01-6
分子式 C18H21ClFN3OS
分子量 381.9
MOL 文件 1366234-01-6.mol
1366234-01-6 結(jié)構(gòu)式 1366234-01-6 結(jié)構(gòu)式

基本信息

英文別名
GSK503A)
GSK 2833503A (GSK2833503A

物理化學(xué)性質(zhì)

溶解度Soluble to 100 mM in DMSO and to 20 mM in ethanol

應(yīng)用領(lǐng)域

用途一
GSK 2833503A is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2833503A (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.
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