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1338483-67-2

英文名稱(chēng) AM-8508
CAS 1338483-67-2
分子式 C19H15FN8
分子量 374.37
MOL 文件 1338483-67-2.mol
1338483-67-2 結(jié)構(gòu)式 1338483-67-2 結(jié)構(gòu)式

基本信息

英文別名
AM-8508
(S)-4-AMINO-6-((1-(6-FLUORO-1-(PYRIDIN-3-YL)-1H-BENZO[D]IMIDAZOL-2-YL)ETHYL)AMINO)PYRIMIDINE-5-CARBONITRILE

應(yīng)用領(lǐng)域

用途一
AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.
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