1338483-10-5
1338483-10-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 AM-9635 英文別名
AM-96355-Pyrimidinecarbonitrile, 4-amino-6-[[(1S)-1-[6-fluoro-1-(5-fluoro-3-pyridinyl)-1H-benzimidazol-2-yl]ethyl]amino]-
(S)-4-AMINO-6-((1-(6-FLUORO-1-(5-FLUOROPYRIDIN-3-YL)-1H-BENZO[D]IMIDAZOL-2-YL)ETHYL)AMINO)PYRIMIDINE-5-CARBONITRILE
物理化學(xué)性質(zhì)
沸點(diǎn)707.4±70.0 °C(Predicted)
密度1.52±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)2.92±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
AM-9635 is a potent and selective PI3Kδ inhibitor. AM-9635 showes good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-96352 inhibits KLH-specific IgG and IgM in a dosedependent manner AM-9635 is well tolerated at all doses and exhibits significantly reduced IgG and IgM specific antibodies . PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.