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130726-68-0

中文名稱 奈康唑
英文名稱 Neticonazole
CAS 130726-68-0
分子式 C17H22N2OS
分子量 302.43
MOL 文件 130726-68-0.mol
更新日期 2023/03/20 15:41:23
130726-68-0 結(jié)構(gòu)式 130726-68-0 結(jié)構(gòu)式

基本信息

中文別名
奈康咗
奈康唑
奈康唑雜質(zhì)
奈康唑粗品
英文別名
Neticonazole
1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole
1-[(E)-2-Methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole
1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl]-1H-imidazole
1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole
1-{(E)-2-(Methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole
1H-Imidazole, 1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-

物理化學(xué)性質(zhì)

熔點37-39°
儲存條件-20°C儲存
溶解度DMSO: 250 mg/mL (826.64 mM)
形態(tài)Solid
顏色White to off-white
奈康唑價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-106541奈康唑
Neticonazole
130726-68-025mg750元
2024/11/08HY-106541奈康唑
Neticonazole
130726-68-010mM * 1mLin DMSO830元
2024/11/08HY-106541奈康唑
Neticonazole
130726-68-050mg1100元

常見問題列表

生物活性
Neticonazole 是一種咪唑衍生物,也是一種有效且長效的抗真菌劑。Neticonazole 具有抗感染和抗癌作用。
靶點

Fungal

體外研究

Neticonazole (10 μM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 μM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole is also an orally active exosome biogenesis and secretion inhibitor.

Western Blot Analysis

Cell Line: C4-2B cells
Concentration: 10 μM
Incubation Time: 48 hours
Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.
體內(nèi)研究

Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.

Animal Model: Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
Dosage: 1 ng/kg, 10 ng/kg and 100 ng/kg
Administration: Oral gavage; daily; for 15 days
Result: Significantly improved the survival of IDB mice with CRC xenograft tumors.
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