1259330-61-4
中文名稱
Sparstolonin B
英文名稱
Sparstolonin B
CAS
1259330-61-4
分子式
C15H8O5
分子量
268.22
MOL 文件
1259330-61-4.mol
1259330-61-4 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
Sparstolonin B 作為選擇性 TLR2 和 TLR4 拮抗劑，選擇性阻斷 TLR2 和 TLR4 介導(dǎo)的炎癥信號(hào)傳導(dǎo)。Sparstolonin B 具有抗 HIV 和抗癌活性。靶點(diǎn)
|
TLR2
|
TLR4
|
HIV-1
|
體外研究
Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.
Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.
Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.
Cell Viability Assay
| Cell Line: | SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells |
| Concentration: | 1 μM, 5 μM, 10 μM or 20 μM |
| Incubation Time: | 2-4 days |
| Result: | Effectively and dose-dependently inhibits the viability of all neuroblastoma cell lines after 2 days (SH-SY5Y and IMR-32), 3 days (NGP cells) or 4 days (SKNF-1 and SK-N-BE(2) cells) treatment. |
體內(nèi)研究
Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.
| Animal Model: | 5-6-week-old male C57Bl/6 mice (body weight 18-20 g) |
| Dosage: | 100 μg/mouse |
| Administration: | I.p. |
| Result: | Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model. |