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12236-82-7

中文名稱 蘭色染料
英文名稱 REACTIVE BLUE 2
CAS 12236-82-7
分子式 C29H20ClN7O11S3
分子量 774.16
MOL 文件 12236-82-7.mol
更新日期 2025/01/13 11:04:37
12236-82-7 結構式 12236-82-7 結構式

基本信息

中文別名
藍色染料
活性藍2
蘭色染料
汽巴藍F3GA
汽巴藍/蘭色染料
C.I.活性藍2
汽巴藍 3GA 瓊脂糖
英文別名
CI 61211
CI NO 61211
PROCION BLUE HB
REACTIVE BLUE 2
GST Inhibitor-1
PROCION BLUE HBS
CIBRACONBLUEF3GA
BASILEN BLUE E-3G
C.I.REACTIVEBLUE2
Kayacion Blue A-B
所屬類別
生物化工:生物染料

物理化學性質

儲存條件2-8°C
溶解度H2O: soluble
形態(tài)saline suspension
顏色dark blue
穩(wěn)定性穩(wěn)定的。與強氧化劑不相容。
CAS 數(shù)據庫12236-82-7

安全數(shù)據

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319
危險品標志Xi
危險類別碼36/37/38
安全說明26-36
WGK Germany3

常見問題列表

生物活性
Procion Blue HB (Reactive Blue 2)是嘌呤能拮抗劑。
體外研究

Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca 2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca 2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca 2+ -dependent manner and induce Ca 2+ oscillations. The application of Reactive Blue 2 increases K + secretion in a dose-dependent manner, and this increase is characterized as a peak followed by a partial relaxation to a steady-state. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion.The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a K i of 8 μM for the membrane-bound kinase, and 6 microM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing. Reactive blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with noradrenaline, ATP and 2-methylthio ATP, but not α,β-methylene ATP, produce relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2. Reactive blue 2, at concentrations of 0.3-10 μM blocks the ATP-induced oscillation in a concentration-dependent manner.

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