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115841-09-3

中文名稱 丹酚酸C
英文名稱 Salvianolicacid C
CAS 115841-09-3
分子式 C26H20O10
分子量 492.43
MOL 文件 115841-09-3.mol
更新日期 2024/12/24 09:24:24
115841-09-3 結(jié)構(gòu)式 115841-09-3 結(jié)構(gòu)式

基本信息

中文別名
丹酚酸C
丹參酚酸C
丹酚酸C對照品,
丹酚酸C(標準品)
丹酚酸C(丹參酚酸C)
英文別名
Salvianolicacid C
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2-propenoyl}oxy)propanoic acid
Benzenepropanoic acid, a-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-,(aR)-
Benzenepropanoic acid, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-
(alphaR)-alpha-[[(2E)-3-[2-(3,4-Dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid
所屬類別
生物化工:提取物

物理化學性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機溶劑,來源于丹參。
沸點844.2±65.0 °C(Predicted)
密度1.570
儲存條件Inert atmosphere,2-8°C
溶解度Soluble in methanol and water
酸度系數(shù)(pKa)2.76±0.10(Predicted)
形態(tài)粉末
顏色黃色

應(yīng)用領(lǐng)域

用途1
用于含量測定/鑒定/藥理實驗等。
藥理藥效:具有一定抗氧化、保護腦組織細胞損傷、保護心腦血管系統(tǒng)和抗HIV作用。
用途2
丹酚酸C 1.具有明顯的抗血小板聚集作用。2.自由基清除劑。

常見問題列表

生物活性
Salvianolic acid C 是細胞色素 P4502C8 (CYP2C8) 的非競爭性抑制劑和細胞色素 P4502J2 (CYP2J2) 中等強度的混合抑制劑,其對 CYP2C8 和 CYP2J2 的 Ki 值分別為 4.82 μM 和 5.75 μM。
靶點

CYP2C8

4.82 μM (Ki)

CYP2J2

5.75 μM (Ki)

體外研究

Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with K i s of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF?κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells.

體內(nèi)研究

Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus.

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