天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>113906-27-7

113906-27-7

中文名稱 PNU 74654,2-PHENOXYBENZOICACID-[(5-METHYL-2-FURANYL)METHYLENE]HYDRAZIDE
英文名稱 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
CAS 113906-27-7
分子式 C19H16N2O3
分子量 320.34
MOL 文件 113906-27-7.mol
更新日期 2023/03/20 15:41:29
113906-27-7 結(jié)構(gòu)式 113906-27-7 結(jié)構(gòu)式

基本信息

中文別名
WNT/Β-CATENIN通路抑制劑(PNU-74654)
英文別名
CS-2563
PNU 74654
PNU74654
PNU 74654
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide
PNU 74654,2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide

物理化學(xué)性質(zhì)

密度1.17±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度二甲基亞砜:>10mg/mL
酸度系數(shù)(pKa)12.12±0.46(Predicted)
形態(tài)固體
顏色白色至灰白色
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20° 下保存長達(dá) 3 個(gè)月。

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼22
WGK Germany3

常見問題列表

生物活性
PNU-74654是Wnt/β-catenin通路的的抑制劑,在NCI-H295 細(xì)胞中的IC50值為129.8 μM。
靶點(diǎn)

129.8 μM (Wnt/β-catenin, NCI-H295 cell)

體外研究

PNU-74654 binds to β-catenin with a K D of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability.

"113906-27-7" 相關(guān)產(chǎn)品信息
1268524-70-4 1268524-69-1 331458-02-7 220904-83-6 128311-08-0 737727-12-7