110115-07-6
中文名稱
CALPAIN INHIBITOR II
英文名稱
CALPAIN INHIBITOR II
CAS
110115-07-6
分子式
C19H35N3O4S
MDL 編號(hào)
MFCD00065506
分子量
401.56
MOL 文件
110115-07-6.mol
更新日期
2024/12/16 10:25:31
110115-07-6 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)676.5±55.0 °C(Predicted)
密度1.076±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度ethanol: 20 mg/mL
酸度系數(shù)(pKa)13.32±0.46(Predicted)
形態(tài)powder
形態(tài)粉末
顏色white
顏色白色
CAS 數(shù)據(jù)庫110115-07-6(CAS DataBase Reference)
常見問題列表
生物活性
ALLM (Calpain inhibitor II) 是鈣蛋白酶 (calpain) 和組織蛋白酶 (cathepsin) 的有效抑制劑。ALLM 抑制脊髓損傷 (SCI) 后神經(jīng)元死亡及改善慢性神經(jīng)功能。體內(nèi)研究
ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death.
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI).
| Animal Model: | Adult male Wistar rats (280-300g) (spinal cord injury model) |
| Dosage: | 0.05, 0.5, and 2.5 mg/kg |
| Administration: | Intraperitoneally; every 24 h for 1 week |
| Result: | Showed significantly better motor function. |