1094250-15-3
1094250-15-3 結(jié)構(gòu)式
基本信息
(1S,2R,5R,6R,7S,8R,10R)-10-(GLYCOLOYLOXY)-8-ISOPROPYL-1,5-DIMETHYL-11-OXATRICYCLO[6.2.1.02,6]UNDEC-7-YL (2E)-3-PHENYLACRYLATE
(?)-Englerin A
(-)-ENGLERIN A
Englerin A high purity
(1S,2R,5R,6R,7S,8R,10R)-10-(Glycoloyloxy)-8-isopropyl-1,5-dimethyl-11-oxatricyclo[6.2.1.02,6]undec-7-yl(2E)-3-phenylacrylate
2-Propenoic acid, 3-phenyl-, (1R,3aR,4S,5R,7R,8S,8aR)-decahydro-5-[(2-hydroxyacetyl)oxy]-1,4-dimethyl-7-(1-methylethyl)-4,7-epoxyazulen-8-yl ester, (2E)-
物理化學(xué)性質(zhì)
常見問題列表
|
hTRPC4 11.2 nM (EC 50 ) |
hTRPC5 7.6 nM (EC 50 ) |
Englerin A (0.15-2500 nM; 48 h) characteristic concentration-dependent suppresses cells growth of the A-498 cells treated with the control siRNA while has little effect on the growth of cells treated with TRPC4 siRNAs.
Englerin A (0.001nM-10 μM; 48 h) inhibits cells viability in HEK293T cells overexpressing TRPC5.
Englerin A (3 nM; 1-240 s) evokes sustained elevation of the intracellular Ca
2+
concentration within 1 min in HEK 293 cells over-expressing human TRPC4.
Englerin A (0.1-1000 nM; 1-300 s) evokes intracellular Ca
2+
elevations in A498 cells as well with an EC
50
of 10 nM.
Englerin A (5 mg/kg; i.p daily except Sunday) markedly inhibits tumor growth during the 2-week treatment period in mice.