107097-80-3
中文名稱
氯谷胺
英文名稱
LOXIGLUMIDE
CAS
107097-80-3
分子式
C21H30Cl2N2O5
分子量
461.38
MOL 文件
107097-80-3.mol
更新日期
2025/01/10 15:39:02
107097-80-3 結(jié)構(gòu)式
基本信息
中文別名
氯谷胺氯谷胺, >98%
英文別名
CS-162cr1505
anoicacid
(+-)--5-oxo
LOXIGLUMIDE
ntanoicacid
Loxiglumide, >98%
LoxigluMide (CR1505)
Loxiglumide >=97% (HPLC)
(+-)-4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxope
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
熔點113-115℃
沸點632.2±55.0 °C(Predicted)
密度1.233±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度二甲基亞砜：≥5mg/mL
酸度系數(shù)(pKa)pKa ~5(at 25℃)
形態(tài)粉末
顏色白色至米色
CAS 數(shù)據(jù)庫107097-80-3
常見問題列表
生物活性
Loxiglumide 是縮膽囊素 (CCK-1) 受體拮抗劑。靶點
CCK-1 receptor
體內(nèi)研究
The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest).