| Identification | Back Directory | [Name]
PaloMid 529 (P529) | [CAS]
914913-88-5 | [Synonyms]
P529
CS-448
SG 00529
PaloMid 529
PaloMid 529 (P529)
Palomid 529, >=98%
Palomid 529 - SG 00529
PaloMid 529 (P529) USP/EP/BP
Palomid 529 (P-529, SG00-529)
P529; PALOMID529; P 529; PALOMID-529; P-529
Palomid 529, 98%, a novel potent inhibitor of both the mTORC1 and mTORC2
3-(4-methoxybenzyloxy)-8-(1-hydroxyethyl)-2-methoxy-6H-benzo[c]chromen-6-one
8-(1-Hydroxyethyl)-2-Methoxy-3-((4-Methoxybenzyl)oxy)-6H-benzo[c]chroMen-6-one
8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]benzo[c]chromen-6-one
8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one
6H-Dibenzo[b,d]pyran-6-one, 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-
8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]-6H-dibenzo[b,d]pyran-6-one Palomid 529 (P529) SG 00529 | [EINECS(EC#)]
806-313-6 | [Molecular Formula]
C24H22O6 | [MDL Number]
MFCD18633224 | [MOL File]
914913-88-5.mol | [Molecular Weight]
406.428 |
| Hazard Information | Back Directory | [Uses]
Palomid 529 is a novel non-steroidal small molecule inhibitor | [Biological Activity]
Palomid 529 (P529) inhibits the mTORC1 and mTORC2 complexes and reduces the phosphorylation of pAktS473, pGSK3βS9 and pS6, but has no effect on pMAPK and pAktT308. Phase 1. | [Enzyme inhibitor]
This novel Akt inhibitor (FW = 406.43 g/mol; CAS 914913-88-5;
Solubility: 80 mg/mL DMSO; <1 mg/mL H2O or Ethanol; Abbreviation:
P529), also named 8- (1-hydroxyethyl) -2-methoxy-3- (4-methoxybenzyloxy)
benzo[c]chromen-6-one, inhibits tumor angiogenesis, vascular permeability,
and tumour growth. P529 has the additional benefit of blocking
pAktS473 signaling consistent with blocking TORC2 in all cells and thus
bypassing feedback loops that lead to increased Akt signaling in some
tumor cells. P529 significantly enhance the antiproliferative effect of
radiation in prostate cancer PC-3 cells. Analysis of signal transduction
pathways targeted by P529 exhibited a decrease in p-Akt, VEGF, MMP-2,
MMP-9, and Id-1 levels after radiation treatment. Palomid 529 is an
effective suppressor of Müller cell proliferation, glial scar formation, and
photoreceptor cell death in a rabbit model of retinal detachment, or RD.
Palomid 529 significantly suppresses breast cancer susceptibility gene
(Brca1) -deficient tumor growth in mice through inhibition of both Akt and
mTOR signaling. | [target]
mTORC1 |
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