| Identification | Back Directory | [Name]
Carboxymethyl cellulose | [CAS]
9004-32-4 | [Synonyms]
b10
cmc2
s75m
cmc7h
7h3sf
carbo
cmc7m
cmc7mt
cmc7l1
lovosa
cmc41a
cmc4h1
cmc4m6
Cellex
CMC-Na
tylosec
cmc3m5t
cellpro
kmts212
kmts300
kmts500
kmts600
nymcels
edifasb
ethoxose
collowel
lovosatn
majolplx
cellugel
cmc7h3sf
cellofas
aku-w515
tylosecr
unisolrh
n(=:)500
C16orf61
AC-DI-SOL
tylose666
tylosedkl
tylosec30
aquaplast
cellofasb
carbose1m
cellofasc
cellogelc
cellogen3h
cellogenpr
carmethose
cellofasb5
blanosebwm
cellofasb6
finegumhes
glikocelta
courlosef4
courlosef8
daicel1150
daicel1180
tylosec300
tylosec600
tylosecr50
sarcelltel
VistecD.1.
tylosecbs30
tylosecbs70
tylosecb200
copagelpb25
nymcelslc-t
nymcelzsb10
nymcelzsb16
courlosef20
cellofasb50
Carbocel C2
Fine Gum G 1
blanosebs190
ac-di-sol.nf
cellogenws-c
courlosef370
lovosa20alk.
modocoll1200
courlosea590
courlosea610
courlosea650
tylosecbr400
sanlosesn20a
tylosec1000p
cellulose gum
polyfibron120
cellufixff100
courlosef1000g
tylosecbseries
Blanose 9M31XF
Thylose sodiuM
POLYCELLPRODUCT
CMC sodium salt
tylosecbrseries
VistecD.1.SGrade
VistecC.1.SGrade
CarboxyMethocel S
sodiumcm-cellulose
nacm-cellulosesalt
b10(polysaccharide)
CrossCarmiloseSodium
lucel(polysaccharide)
cm-cellulosesodiumsalt
Aquacide I, Calbiochem
Aquacide II, Calbiochem
Carboxymethyl cellulose
CMC)CarboxyMethyl cellu
sodiumglycolatecellulose
cellulosesodiumglycolate
Na-CarboxyMethylcellulose
CMC/CarboxyMethyl Cellulose
Polyanionic Cellulose (PAC)
carbomethoxyethercellulose,
sodiumcarboxmethylcellulose
Carboxy methyl cellulose 1M6
CELLULOSEGUM,LOWVISCOSITY,FCC
Sodium carboxymethyl celluose
Carboxyl Methyl Cellulose(CMC)
CarboxyMethyl Cellulose-Na Salt
CARBOXYMETHYLCELLULOSE SODIUM LV
Carboxyl Methyl Cellulose sodium
Carboxymethycelluose sodium salt
SodiumCarboxymethylCellulose,>99%
CARBOXYMETHYLCELLULOSESODIUM(FOOD)
CARBOXYMETHYLCELLULOSESODIUM(TECH)
Carboxymethyl Cellulose Sodium，CMC
sodiumsaltofcarboxymethylcellulose
CARBOXYMETHYLCELLULOSESODIUM(PHARM)
CarboxyMethyl Cellulose SodiuM
Carboxymethylzellulose, Natriumsalz
CARBOXYMETHYL CELLULOSE HIGH VISCOSI
CARBOXYMETHYL CELLULOSE SODIUM MEDIU
CARBOXYMETHYLCELLULOSE SODIUM MEDIUM
CARBOXYMETHYLCELLULOSE SODIUM SALT M
CARBOXYMETHYLCELLULOSE SODIUMLOW VIS
SCMC(SODIUM CARBOXY METHYL CELULLOSE
SODIUM CARBOXY METHYL CELLULOSE (CMC)
Cellulose carboxymethyl ether, sodium
CARBOXYMETHYLCELLULOSESODIUM(NEUTRAL)
carbomethoxyethercellulose,sodiumsalt
Carboxymethylcellulose Sodium (1.5 g)
sodium carboxymethyl cellulose(CMC-Na)
CARBOXYMETHYL CELLULOSE HIGH VISCOSITY
SODIUM CARBOXYMETHYL CELLULOSE 62% MIN.
Carboxymethyl Cellulose Sodium n(=:)500
CarboxyMethyl cellulose sodiuM salt USP
SodiuM carboxyMethyl cellulose, 800 cps
Carboxymethyl Cellulose Sodium n(=:)1050
CARBOXYMETHYLCELLULOSESODIUM(ALKALINITY)
Cellulose carboxymethyl ether sodium salt
Carboxymethyl Cellulose Sodium Salt 〔CMC〕
Sodium carboxy methyl cellulose,food grade
Sodium carboxymethyl cellulose: (Dowex 11)
CarboxyMethyl cellulose, sodiuM salt, aver
Sodium carboxy methyl cellulose, alkalinity
Carboxymethylcellulose sodium salt 800～1200
CARBOXYMETHYLCELLULOSESODIUM(HIGHVISCOSITY)
CARBOXYMETHYLCELLULOSE SODIUMLOW VISCOSI TY
COX assembly mitochondrial protein 2 homolog
Sodium carboxymethylcellulose,high viscosity
Sodium carboxymethyl cellulose
Sodium Tylose
CARBOXYMETHYLCELLULOSESODIUM,LOWVISCOSITY,USP
carbomethoxyethercellulose,sodiumsaltchemical
CARBOXYMETHYLCELLULOSESODIUM,HIGHVISCOSITY,USP
CARBOXYMETHYL CELLULOSE SODIUM MEDIUMVIS COSITY
CARBOXYMETHYLCELLULOSE SODIUM SALT HIGH VISCOSITY
CARBOXYMETHYLCELLULOSE SODIUM SALT LOW V ISCOSITY
SodiuM carboxyMethyl cellulose average Mw ~90,000
ANTI-DC13(N-TERMINAL) antibody produced in rabbit
SodiuM carboxyMethyl cellulose average Mw ~250,000
SodiuM carboxyMethyl cellulose average Mw ~700,000
CARBOXYMETHYLCELLULOSE SODIUM MEDIUMVISC OSITY USP
Carboxymethyl Cellulose Sodium Salt (n=approx. 500)
CARBOXYMETHYLCELLULOSE SODIUM SALT MEDIU M VISCOSITY
Carboxymethyl Cellulose Sodium Salt (n=approx. 1,050)
CarboxymethylCelluloseSodiumSalt(MedViscosity500-600Cps
CarboxymethylCelluloseSodiumSaltHighViscosity500-600Cps
CARBOXYMETHYLCELLULOSE SODIUM SALT ULTRA HIGH VISCOSITY
CARBOXYMETHYL CELLULOSE, SODIUM SALT, UL TRA LOW VISCOSITY
Dai-Ichi Cellogen 7A, BSH-5, 6A, WS-A, F-SH, HS-SH, HP-4H,
CARBOXYMETHYL CELLULOSE SODIUM SALT (MED VISCOSITY 250 - 350 cps
Carboxymethyl cellulose, sodium salt, average M.W. 90000 (DS=0.7)
Sodium carboxymethyl cellulose,Carboxymethylcellulose sodium salt
Carboxymethylecellulose, sodium salt, Average M.W. 90000 (DS=0.7)
Carboxymethylecellulose, sodium salt, Average M.W. 250000 (DS=0.7)
Carboxymethylecellulose, sodium salt, Average M.W. 250000 (DS=0.9)
Carboxymethylecellulose, sodium salt, Average M.W. 700000 (DS=0.9)
Carboxymethylecellulose, sodium salt, Average M.W. 250000 (DS=1.2)
Carboxymethyl cellulose, sodium salt, average M.W. 250000 (DS=0.7)
Carboxymethyl cellulose, sodium salt, average M.W. 250000 (DS=0.9)
Carboxymethyl cellulose, sodium salt, average M.W. 250000 (DS=1.2)
Carboxymethyl cellulose, sodium salt, average M.W. 700000 (DS=0.9)
CarboxyMethyl cellulose, sodiuM salt, average M.W. 90000 (DS=0.7) 1KG
Carboxymethylcellulose sodium salt, Sodium carboxymethylcellulose
CarboxyMethyl cellulose, sodiuM salt, average M.W. 250000 (DS=0.7) 1KG
CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 90,000, DS = 0.7
CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 250,000, DS = 0.7
CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 700,000, DS = 0.9
CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 250,000, DS = 1.2
CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 250,000, DS = 0.9
CarboxyMethyl cellulose, sodiuM salt, average M.W. 90000 (DS=0.7) 100GR
Sodium carboxymethyl cellulose average Mw ~250,000, degree of substitution 0.7
Sodium carboxymethyl cellulose average Mw ~250,000, degree of substitution 0.9
Sodium carboxymethyl cellulose average Mw ~250,000, degree of substitution 1.2
CarboxyMethylcellulose SodiuM, Low Viscosity, Viscosity of 2 Percent Aqueous Solution @ 25 DEG C: 10-50 cP, USP
CarboxyMethylcellulose SodiuM, Low Viscosity, Viscosity of 2 Percent Aqueous Solution @ 25 DEG C: 10-50 cps, USP, EP
CarboxyMethylcellulose SodiuM, MediuM Viscosity, Viscosity of 2 Percent Aqueous Solution @ 25 DEG C: 400-800 cP, USP
CarboxyMethylcellulose SodiuM, High Viscosity, Viscosity of 1 Percent Aqueous Solution @ 25 DEG C: 1500-3000 cP, USP
CarboxyMethylcellulose SodiuM, MediuM Viscosity, Viscosity of 2 Percent Aqueous Solution @ 25 DEG C: 400-800 cP, USP, EP
Cellulose Glycolic Acid Sodium Salt
Sodium Carboxymethyl Cellulose
Sodium Cellulose Glycolate
Sodium Tylose
Tylose Sodium
Carboxymethylcellulose sodium salt
Carboxymethyl cellulose, sodium salt
Carboxymethyl cellulose
Sodium Tylose
CMC
Tylose Sodium
Sodium Cellulose Glycolate | [EINECS(EC#)]
900-432-4 | [Molecular Formula]
C6H7O2(OH)2CH2COONa | [MDL Number]
MFCD00675913 | [MOL File]
9004-32-4.mol |
| Chemical Properties | Back Directory | [Definition]
A semisynthetic, water-soluble polymer in which
CH
2
COOH groups are substituted on the glucose
units of the cellulose chain through an ether link-
age. Mw ranges from 21,000 to 500,000. Since the
reaction occurs in an alkaline medium, the prod-
uct is the sodium salt of the carboxylic acid R-O-
CH
2
COONa. | [Appearance]
solid | [Melting point ]
274 °C (dec.)
| [density ]
1,6 g/cm3 | [FEMA ]
2239 | CARBOXYMETHYLCELLULOSE | [storage temp. ]
room temp | [solubility ]
H2O: 20 mg/mL, soluble
| [form ]
low viscosity
| [pka]
4.30(at 25℃) | [color ]
White to light yellow | [Odor]
Odorless | [PH]
pH (10g/l, 25℃) 6.0～8.0 | [PH Range]
6.5 - 8.5 | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
soluble | [Merck ]
14,1829 | [Uses]
cellulose gum (Carboxymethyl cellulose) is a thickener, binder, and emulsifier equivalent to cellulose fiber. It is resistant to bacterial decomposition and provides a product with uniform viscosity. It can prevent skin moisture loss by forming a film on the skin’s surface, and also help mask odor in a cosmetic product. Constituents are any of several fibrous substances consisting of the chief part of a plant’s cell walls (often extracted from wood pulp or cotton). | [EPA Substance Registry System]
Cellulose, carboxymethyl ether, sodium salt(9004-32-4) |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Uses]
In drilling muds, in detergents as a soil-suspending agent, in resin emulsion paints, adhesives, printing inks, textile sizes, as protective colloid in general. As stabilizer in foods. Pharmaceutic aid (suspending agent; tablet excipient; viscosity-increasing agent). | [Production Methods]
Alkali cellulose is prepared by steeping cellulose obtained from
wood pulp or cotton fibers in sodium hydroxide solution. The
alkaline cellulose is then reacted with sodium monochloroacetate to
produce carboxymethylcellulose sodium. Sodium chloride and
sodium glycolate are obtained as by-products of this etherification. | [Brand name]
Celluvisc (Allergan); Refresh Plus, Cellufresh
Formula (Allergan). | [General Description]
Sodium carboxymethyl cellulose (CMC,9004-32-4) belongs to the class of anionic linear structured cellulose. Its components consist of polysaccharide composed of fibrous tissues of plants. It is a water soluble polymer which can be used as a polyelectrolyte cellulose derivative.
| [Pharmaceutical Applications]
Sodium carboxymethyl cellulose (NaCMC,9004-32-4) is the sodium salt of carboxymethyl cellulose, an anionic derivative.It is widely used in oral and topical pharmaceutical formulations, primarily for its viscosity-increasing properties. Viscous aqueous solutions are used to suspend powders intended for either topical application or oral and parenteral administration. Carboxymethylcellulose sodium may also be used as a tablet binder and disintegrant, and to stabilize emulsions.
Higher concentrations, usually 3–6%, of the medium-viscosity grade are used to produce gels that can be used as the base for applications and pastes; glycols are often included in such gels to prevent them drying out. Carboxymethylcellulose sodium is also used in self-adhesive ostomy, wound care, and dermatological patches as a muco-adhesive and to absorb wound exudate or transepidermal water and sweat. This muco-adhesive property is used in products designed to prevent post-surgical tissue adhesions; and to localize and modify the release kinetics of active ingredients applied to mucous membranes; and for bone repair. Encapsulation with carboxymethylcellulose sodium can affect drug protection and delivery. There have also been reports of its use as a cyto-protective agent.
Carboxymethylcellulose sodium is also used in cosmetics, toiletries, surgical prosthetics, and incontinence, personal hygiene, and food products.
| [Safety]
Carboxymethylcellulose sodium(9004-32-4) is used in oral, topical, and some
parenteral formulations. It is also widely used in cosmetics,
toiletries, and food products, and is generally regarded as a
nontoxic and nonirritant material. However, oral consumption of
large amounts of carboxymethylcellulose sodium can have a
laxative effect; therapeutically, 4–10 g in daily divided doses of the
medium- and high-viscosity grades of carboxymethylcellulose
sodium have been used as bulk laxatives.
The WHO has not specified an acceptable daily intake for
carboxymethylcellulose sodium as a food additive since the levels
necessary to achieve a desired effect were not considered to be a
hazard to health. However, in animal studies, subcutaneous
administration of carboxymethylcellulose sodium has been found to
cause inflammation, and in some cases of repeated injection
fibrosarcomas have been found at the site of injection.
Hypersensitivity and anaphylactic reactions have occurred in
cattle and horses, which have been attributed to carboxymethylcellulose
sodium in parenteral formulations such as vaccines and
penicillins.
LD50 (guinea pig, oral): 16 g/kg
LD50 (rat, oral): 27 g/kg
| [storage]
Carboxymethylcellulose sodium is a stable, though hygroscopic
material. Under high-humidity conditions, carboxymethylcellulose
sodium can absorb a large quantity (>50%) of water. In tablets, this
has been associated with a decrease in tablet hardness and an
increase in disintegration time.
Aqueous solutions are stable at pH 2–10; precipitation can occur
below pH 2, and solution viscosity decreases rapidly above pH 10.
Generally, solutions exhibit maximum viscosity and stability at pH
7–9.
Carboxymethylcellulose sodium may be sterilized in the dry state
by maintaining it at a temperature of 1608℃ for 1 hour. However,
this process results in a significant decrease in viscosity and some
deterioration in the properties of solutions prepared from the
sterilized material.
Aqueous solutions may similarly be sterilized by heating,
although this also results in some reduction in viscosity. After
autoclaving, viscosity is reduced by about 25%, but this reduction is
less marked than for solutions prepared from material sterilized in
the dry state. The extent of the reduction is dependent on the
molecular weight and degree of substitution; higher molecular
weight grades generally undergo a greater percentage reduction in
viscosity. Sterilization of solutions by gamma irradiation also
results in a reduction in viscosity.
Aqueous solutions stored for prolonged periods should contain
an antimicrobial preservative.
The bulk material should be stored in a well-closed container in a
cool, dry place. | [Properties and Applications]
|
TEST ITEMS
|
SPECIFICATION
|
|
CMC-LV
|
CMC-HV
|
|
Appearance
|
Cream colored and free
flowing powder
|
Cream colored and free flowing powder
|
|
Degree of Substitution
|
0.6-0.9
|
0.6-0.9
|
|
pH
|
6-9
|
6-9
|
|
Moisture %
|
10% max
|
10% max
|
|
Sodium CMC content on dry basis
|
70% min
|
70% min
|
|
Viscosity at 600RPM
|
90 max in deionized water
10 max 4% salt water mud,API water loss
|
30 max in deionized water
30 min in 4% salt water
30 min in 4% saturated salt water
10 max 4% salt water mud,API water loss
|
| [Purification Methods]
Dialyse it for 48hours against distilled water and freeze-dry if a solid is required. | [Incompatibilities]
Carboxymethylcellulose sodium is incompatible with strongly
acidic solutions and with the soluble salts of iron and some other
metals, such as aluminum, mercury, and zinc. It is also incompatible
with xanthan gum. Precipitation may occur at pH < 2, and also
when it is mixed with ethanol (95%).
Carboxymethylcellulose sodium forms complex coacervates
with gelatin and pectin. It also forms a complex with collagen
and is capable of precipitating certain positively charged proteins. | [Regulatory Status]
GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (dental preparations; intraarticular,
intrabursal, intradermal, intralesional, and intrasynovial
injections; oral drops, solutions, suspensions, syrups and tablets;
topical preparations). Included in nonparenteral medicines licensed
in the UK. Included in the Canadian List of Acceptable Nonmedicinal
Ingredients. |
| Safety Data | Back Directory | [Risk Statements ]
40 | [Safety Statements ]
24/25 | [WGK Germany ]
1
| [RTECS ]
FJ5950000
| [F ]
3 | [Autoignition Temperature]
698 °F | [TSCA ]
Yes | [HS Code ]
39123100 | [Safety Profile]
Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. It migrates to food from packagmg materials. When heated to decomposition it emits toxic fumes of NazO. See also POLYMERS, SOLUBLE. | [Reaction]
Highly efficient catalyst for the hydrogenation of aldehydes and ketones. This hydrogenation catalyst represents a versatile replacement of hydride-based reducing agents.
| [Toxicity]
LD50 oral in rabbit: > 27gm/kg |
| Questions And Answer | Back Directory | [description]
Sodium carboxymethyl cellulose(9004-32-4) is a water-soluble polymer. As a solution in water, it has thixotropic properties. It is useful in helping to hold the components of pyrotechnic compositions in aqucous suspension (e.g., in the making of black match). It is also an especially effective binder that can be used in small amounts in compositions, where the binder can intcrfere with the intended effect (e.g., in strobe compositions). However, its sodium content obviously precludes its use in most color compositions. Sodium carboxymethyl-cellulose is manufactured from cellulose by various proccsses that replacc some of the hy drogen atoms in the hydroxyl[OH] groups of the cellulose molecule with acidic carboxymethyl [-CH2CO.OH] groups，which are neutralized to form the corresponding sodium salt. Sodium carboxymethyl cellulose is white when pure; industrial grade material may be grayish-white or cream granules or powder.
| [Product Features]
Carboxymethyl cellulose (CMC) is tackifier, at room temperature, it is non-toxic tasteless white flocculent powder, it is stable and soluble in water, aqueous solution is neutral or alkaline transparent viscous liquid, it is soluble in other water-soluble gums and resins, it is insoluble in organic solvents such as ethanol. Carboxymethyl cellulose is the substituted product of cellulosic carboxymethyl group. According to their molecular weight or degree of substitution, it can be completely dissolved or insoluble polymer, the latter can be used as the weak acid cation of exchanger to separate neutral or basic proteins.
Carboxymethyl cellulose can form highly viscous colloidal solution with adhesive, thickening, flowing, emulsifying, shaping, water, protective colloid, film forming, acid, salt, suspensions and other characteristics, and it is physiologically harmless, so it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.
| [Uses]
Sodium carboxymethyl cellulose (CMC,9004-32-4) is frequently called simply carboxymethyl cellulose and also known as cellulose gum. It is derived from purified cellulose from cotton and wood pulp. It is a water dispersible sodium salt of carboxy-methyl ether of cellulose that forms a clear colloidal solution. It is a hygroscopic material that has the ability to absorb more than 50% of water at high humidity. It is also a natural polymeric derivative that can be used in detergents, food and textile industries.
CMC is one of the most important products of cellulose ethers, which are formed by natural cellulose modification as a kind of cellulose derivate with an ether structure. Due to the fact that the acid form of CMC has poor water solubility, it is usually preserved as sodium carboxymethylcellulose, which is widely used in many industries and regarded as monosodium glutamate in industry.
CMC is used in cigarette adhesive, fabric sizing, footwear paste meal, home slimy. It is used in interior painting architectural, building lines melamine, thickening mortar, concrete enhancement. It is used in refractory fiber, ceramic production molding bond. It is used in oil drilling, exploration address slurry thickening, reducing water loss, quality paper surface sizing. It can be used as soap and washing powder detergent active additives, as well as other industrial production on the dispersion, emulsification, stability, suspension, film, paper, polishing and the like. Quality product can be used for toothpaste, medicine, food and other industrial sectors.
| [Synthesis]
Sodium carboxymethyl cellulose is formed when cellulose reacts with mono chloroacetic acid or its sodium salt under alkaline condition with presence of organic solvent, hydroxyl groups substituted by Sodium carboxymethyl groups in C2, C3 and C6 of glucose, which substitution slightly prevails at C2 position.
Generally, there are two steps in manufacturing process of sodium carboxymethyl cellulose, alkalinization and etherification.
Step 1: Alkalinization
Disperse the raw material cellulose pulp in alkali solution (generally sodium hydroxide, 5–50%) to obtain alkali cellulose.
Cell-OH+NaOH →Cell·O-Na+ +H2O
Step 2: Etherification
Etherification of alkali cellulose with sodium monochloroacetate (up to 30%) in an alcohol-water medium. The mixture of alkali cellulose and reagent is heated (50–75°C) and stirred during the process.
ClCH2COOH+NaOH→ClCH2COONa+H2O
Cell·O-Na+ +ClCH2COO- →Cell-OCH2COO-Na
The DS of the sodium CMC can be controlled by the reaction conditions and use of organic solvents (such as isopropanol).
https://www.longdom.org
https://foodadditives.net | [Usage Instruction]
Use warm water or cold water when preparing the solution, and stir till it completely melts. The amout of added water depends on variety and the use of multiple requirements.
High viscosity sodium carboxymethyl cellulose (HV-CMC) is a white or slightly yellow fibrous powder, hygroscopic, odorless, tasteless, non-toxic, easy to ferment, insoluble in acids, alcohols and organic solvents, easily dispersed to form colloidal solution in water. It is reacted by the acid and fibrous cotton, it is mainly used for water-based drilling fluids tackifier, it has certain role of fluid loss, it has strong salt and temperature resistance especially.
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