| Identification | More | [Name]
4,4'-Bis(dimethylamino)benzophenone | [CAS]
90-94-8 | [Synonyms]
4,4'-BIS(DIMETHYLAMINO)BENZOPHENONE
BIS-DIMETHYLAMINOPHENYLMETHANONE
BIS(P-DIMETHYLAMINOPHENYL)KETONE
LABOTEST-BB LT00086928
MICHLER KETONE
MICHLERS KETONE
MICHLER'S KETONE
N,N,N',N'-TETRAMETHYL-4,4'-DIAMINOBENZOPHENONE
N,N,N,N'-TETRAMETHYL-4,4'-DIAMINOBENZOPHENONE
P,P'-TETRAMETHYLDIAMINOBENZOPHENONE
TETRAMETHYL-P,P'-DIAMINOBENZOPHENONE
(Tetramethyldiamino)benzophenone
4,4’-bis(dimethylamino)-benzophenon
4,4’-bis(n,n-dimethylamino)benzophenone
4,4’-Di(N,N-dimethylamino)benzophenone
4,4’-di(N,N-Dimethylamino)diphenylketone
4,4’-Tetramethyldiaminobenzophenone
4,4'-di(Dimethylamino)benzophenone
ai3-22412
Benzophenone, 4,4'-bis(dimethylamino)- | [EINECS(EC#)]
202-027-5 | [Molecular Formula]
C17H20N2O | [MDL Number]
MFCD00008312 | [Molecular Weight]
268.35 | [MOL File]
90-94-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Michler’s ketone is a is a blue powder or
white to green-colored leaflet material. | [Melting point ]
174 -176 °C(lit.)
| [Boiling point ]
360 °C
| [density ]
1.0208 (rough estimate) | [refractive index ]
1.5486 (estimate) | [Fp ]
220 °C
| [storage temp. ]
Store below +30°C. | [solubility ]
ethanol: 5 mg/mL, clear
| [form ]
Powder | [pka]
2.55±0.12(Predicted) | [color ]
Blue to dark blue or gray | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents. | [Water Solubility ]
400 mg/L (20 ºC) | [Merck ]
14,6177 | [BRN ]
790733 | [InChIKey]
VVBLNCFGVYUYGU-UHFFFAOYSA-N | [CAS DataBase Reference]
90-94-8(CAS DataBase Reference) | [IARC]
2B (Vol. 99) 2010 | [NIST Chemistry Reference]
Methanone, bis[4-(dimethylamino)phenyl]-(90-94-8) | [EPA Substance Registry System]
90-94-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R45:May cause cancer.
R41:Risk of serious damage to eyes.
R68:Possible risk of irreversible effects.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2811 | [WGK Germany ]
3
| [RTECS ]
DJ0250000
| [Autoignition Temperature]
480 °C | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29223990 | [Safety Profile]
Confirmed human
carcinogen with experimental carcinogenic
and neoplastigenic data. A poison by
ingestion. Mutation data reported. A
flammable liquid. When heated to
decomposition it emits toxic fumes of NOx. | [Hazardous Substances Data]
90-94-8(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: > 6400 mg/kg |
| Hazard Information | Back Directory | [General Description]
White to greenish crystalline leaflets or blue powder. | [Reactivity Profile]
MICHLER'S KETONE(90-94-8) is incompatible with strong oxidizing agents and strong reducing agents . | [Air & Water Reactions]
Insoluble in water. | [Potential Exposure]
Mutagen. Animal Carcinogen.
Michler’s ketone is a dye intermediate and derivative of
dimethylaniline. It is also used in antifreeze formulations,
cosmetics, cleaning compounds; heat transfer fluids;
as a chemical intermediate in the synthesis of at least 13
dyes and pigments, especially auramine derivatives. | [Fire Hazard]
Literature sources indicate that this chemical is combustible. | [First aid]
Skin Contact: Flood all areas of body that
have contacted the substance with water. Don’t wait to
remove contaminated clothing; do it under the water stream.
Use soap to help assure removal. Isolate contaminated clothing
when removed to prevent contact by others. Eye
Contact: Remove any contact lenses at once. Immediately
flush eyes well with copious quantities of water or normal
saline for at least 20 30 minutes. Seek medical attention.
Inhalation: Leave contaminated area immediately; breathe
fresh air. Proper respiratory protection must be supplied to
any rescuers. If coughing, difficult breathing or any other
symptoms develop, seek medical attention at once, even if
symptoms develop many hours after exposure. Ingestion: If
unconscious or convulsing, do not induce vomiting or give
anything by mouth. Assure that victim’s airway is open and
lay him on his side with his head lower than his body and
transport at once to a medical facility. If conscious and not
convulsing, give a glass of water to dilute the substance, If
medical advice is not readily available, do not induce vomiting,
and rush the victim to the nearest medical facility. | [Shipping]
UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates,
solid, toxic, n.o.s., Hazard Class: 6.1; Labels:
6.1-Poison Inhalation Hazard. UN2811 Toxic solids,
organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous
materials, Technical Name Required. UN1602 Dyes, liquid,
toxic, n.o.s or Dye intermediates, liquid, toxic, n.o.s.,
Hazard Class: 6.1; Labels: 6.1-Poisonous materials. | [Incompatibilities]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from aldehydes, alkaline
materials, strong acids, strong bases, strong reducing
agents such as hydrideds and active metals. Contact
with hydrogen peroxide may form heat- and shock- sensitive
explosives. | [Description]
Michler's ketone is a blue powder or white togreen-colored leaflet material. Molecular weight = 268.37;Boiling point ≥360℃ (decomposition); Freezing/Meltingpoint= 172-176*C; Flash point = 220-C; Autoignitiontemperature = 480PC. Hazard Identification (based onNFPA-704 M Rating System): Health 3, Flammability 1,Reactivity 0. Insoluble in water. | [Chemical Properties]
Michler’s ketone is a is a blue powder or
white to green-colored leaflet material. | [Chemical Properties]
white to light greenish crystals | [Waste Disposal]
Do not discharge into drains
or sewers. Consult with environmental regulatory agencies
for guidance on acceptable disposal practices. If allowed,
Incineration with effluent gas scrubbing is recommended.
Containers must be disposed of properly by following
package label directions or by contacting your local or
federal environmental control agency, or by contacting
your regional EPA office. | [Uses]
In manufacture of dyes and pigments. | [Definition]
ChEBI: 4,4'-Bis(dimethylamino)benzophenone is a member of benzophenones. | [Synthesis Reference(s)]
Tetrahedron, 38, p. 1163, 1982 DOI: 10.1016/0040-4020(82)85099-0 | [Hazard]
Possible carcinogen. | [Carcinogenicity]
Michler’s ketone is reasonably anticipated to be a human cagen based on sufficient evidence of carcinogenicity from stud
rcinoies in experimental animals. | [storage]
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in a refrigerator or a cool, dry place awayfrom peroxides, aldehydes, strong acids. Where possible,automatically pump liquid from drums or other storage containers to process containers. A regulated, marked areashould be established where this chemical is handled, used,or stored in compliance with OSHA Standard 1910.1045. | [Purification Methods]
Dissolve the ketone in dilute HCl, filter and precipitate it by adding ammonia (to remove water-insoluble impurities such as benzophenone). Then crystallise it from EtOH or pet ether. [Suppan J Chem Soc, Faraday Trans1 71 539 1975.] It is also purified by dissolving in *benzene, then washing with water until the aqueous phase is colourless. The *benzene is evaporated off, and the residue is recrystallised three times from *benzene and EtOH [Hoshino & Kogure J Phys Chem 72 417 1988]. [Beilstein 14 IV 255.] |
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